TGM2
Sign in to saveAlso known as G-ALPHA-h, GNAH, HEL-S-45, TG2, TGC, TG(C), transglutaminase 2, G(h)
protein-coding gene in the species Homo sapiens
Gene data
TGM2- Name
- transglutaminase 2
- Type
- protein-coding
- Position
- 38,127,385–38,168,463 (−)
- Aliases
- G(h), TG(C), TGC, hTG2, tTG
- Ensembl
- ENSG00000198959
- RefSeq RNA
- NM_001323316.2, NM_001323317.2, NM_001323318.2, NM_004613.4, NM_198951.3
- RefSeq protein
- NP_001310245.1, NP_001310246.1, NP_001310247.1, NP_004604.2, NP_945189.1
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
transglutaminase 2
- Symbol
- TGM2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:38,127,385-38,168,463
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Tissue transglutaminase.png
Show 9 more facts
- found in taxon
- Homo sapiens
- HomoloGene ID
- 3391
- exact match
- identifiers.org/ncbigene/7052
- genomic end
- 36794980
- genomic start
- 38127385
- chromosome
- human chromosome 20
- Commons category
- Tissue transglutaminase
- cytogenetic location
- 20q11.23
- expressed in
- decidua
via Wikidata · CC0