Structure via PubChem · Public domain (PubChem)
thiotepa
Sign in to saveThiotepa (N,N',N''(-triethylenethiophosphoramide, INN), sold under the brand name Tepadina among others, is an anti-cancer medication.
Chemical data
- Formula
- C6H12N3PS
- Molecular weight
- 189.22 g/mol
- IUPAC name
- tris(aziridin-1-yl)-sulfanylidene-lambda5-phosphane
- SMILES
- C1CN1P(=S)(N2CC2)N3CC3
- InChIKey
- FOCVUCIESVLUNU-UHFFFAOYSA-N
- XLogP
- 0.5
- Polar surface area
- 41.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
3,849 papers- Thiotepa.IARC monographs on the evaluation of carcinogenic risks to humans · 1990
- Revisiting intrathecal thiotepa: Efficacy and safety in secondary CNS malignancies.Medical oncology (Northwood, London, England) · 2024
- Thiotepa.Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses · 1991
- Thiotepa.Report on carcinogens : carcinogen profiles · 2011
- Thiotepa-induced leukoderma.Archives of dermatology · 1979
via PubMed
Wikidata facts
- Mass
- 189.048955
Show 4 more facts
- chemical formula
- C₆H₁₂N₃PS
- World Health Organisation international non-proprietary name
- thiotepa
- canonical SMILES
- C1CN1P(=S)(N2CC2)N3CC3
- Commons category
- Thiotepa
via Wikidata · CC0
~18 min read
Article
14 sectionsContents
- History
- Structure
- Reactivity
- Synthesis
- Medical uses
- Administration
- Clinical outcomes
- Metabolism
- Molecular mechanism of action
- Toxicity
- Myelosuppression
- Additional toxic effects
- Drug interactions
- References
Thiotepa (N,N',N''(-triethylenethiophosphoramide, INN), sold under the brand name Tepadina among others, is an anti-cancer medication.
Thiotepa is an organophosphorus compound with the formula (C2H4N)3PS.
Gallery (4)
Connections
chemotherapy
Entity
Hodgkin lymphoma
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aziridine
Entity
bone marrow suppression
Disease
tiazofurin
Entity
Japan
Country
cancer
Entity
liver
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kidney
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International Standard Book Number
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acid
Entity
plastic
Entity
urine
Entity
physiology
Entity
diarrhea
Entity
birth control
Entity
pH
Entity
anemia
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digital object identifier
Entity
breast cancer
Entity
Categories
1-Aziridinyl compoundsAlkylating antineoplastic agentsCancer treatmentsCYP2B6 inhibitorsDrugboxes which contain changes to verified fieldsDrugboxes which contain changes to watched fieldsDrugs with non-standard legal statusECHA InfoCard ID from WikidataIARC Group 1 carcinogensInfobox drug articles with non-default infobox titleOrganophosphoric amidesOrphan drugsThiophosphoryl compounds