Structure via PubChem · Public domain (PubChem)
torasemide
Sign in to saveAlso known as AC-4464, AC4464, BM-02015, N-(((1-methylethyl)amino)carbonyl)-4-((3-methylphenyl)amino)-3-pyridinesulfonamide, 1-isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea, torsemide
Torasemide, also known as torsemide, is a diuretic medication used to treat fluid overload due to heart failure, kidney disease, and liver disease. It is a less preferred treatment for high blood pressure. It is taken by mouth or by injection into a vein.
Chemical data
- Formula
- C16H20N4O3S
- Molecular weight
- 348.4 g/mol
- IUPAC name
- N-[4-(3-methylanilino)pyridin-1-ium-3-yl]sulfonyl-N'-propan-2-ylcarbamimidate
- SMILES
- CC1=CC(=CC=C1)NC2=C(C=[NH+]C=C2)S(=O)(=O)NC(=NC(C)C)[O-]
- InChIKey
- NGBFQHCMQULJNZ-UHFFFAOYSA-N
- XLogP
- 3.8
- Polar surface area
- 116 Ų
- H-bond donors
- 3
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1993
- Admin. routes
- oral, parenteral
- Indications
- cardiovascular disease, heart failure, preeclampsia, congestive heart failure
via ChEMBL · EBI
Research
698 papers- Torasemide in Hypertension and Heart Failure: Re-inventing Loop Diuretic Therapy?Current pharmaceutical design · 2021
- Torasemide versus furosemide in treatment of heart failure: A systematic review and meta-analysis of randomized controlled trials.Journal of evaluation in clinical practice · 2020
- Torasemide prolonged release.Drugs · 2009
- Torasemide. An update of its pharmacological properties and therapeutic efficacy.Drugs · 1995
- [Torasemide].Revista de medicina de la Universidad de Navarra · 1996
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 348.125612
- Has use
- medication
Show 6 more facts
- Commons category
- Torasemide
- chemical formula
- C₁₆H₂₀N₄O₃S
- canonical SMILES
- CC1=CC(=CC=C1)NC2=C(C=NC=C2)S(=O)(=O)NC(=O)NC(C)C
- World Health Organisation international non-proprietary name
- torasemide
- subject has role
- diuretic
- defined daily dose
- 15
via Wikidata · CC0
~3 min read
Encyclopedic overview
6 sectionsContents
- Medical uses
- Adverse effects
- Chemistry
- Names
- Veterinary uses
- References
Torasemide, also known as torsemide, is a diuretic medication used to treat fluid overload due to heart failure, kidney disease, and liver disease. It is a less preferred treatment for high blood pressure. It is taken by mouth or by injection into a vein.
Common side effects include headache, increased urination, diarrhea, cough, and dizziness. Other side effects may include hearing loss and low blood potassium. Torasemide is a sulfonamide and loop diuretic. Use is not recommended in pregnancy or breastfeeding. It works by decreasing the reabsorption of sodium by the kidneys.
Excerpted from Wikipedia’s “torasemide” article, available under the CC BY-SA 4.0 licence.