Structure via PubChem · Public domain (PubChem)
trichlormethiazide
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Trichlormethiazide (INN, currently being sold under the brand names of Achletin, Diu-Hydrin and Triflumen) is a diuretic with properties similar to those of hydrochlorothiazide. It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension. In veterinary medicine, trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal limbs and general bruising.
Chemical data
- Formula
- C8H8Cl3N3O4S2
- Molecular weight
- 380.7 g/mol
- IUPAC name
- 6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
- SMILES
- C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)NC(N2)C(Cl)Cl
- InChIKey
- LMJSLTNSBFUCMU-UHFFFAOYSA-N
- XLogP
- 0.6
- Polar surface area
- 135 Ų
- H-bond donors
- 3
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1960
- Admin. routes
- oral
- Indications
- cardiovascular disease
via ChEMBL · EBI
Research
348 papersvia PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 378.902181
- Has use
- medication
Show 5 more facts
- chemical formula
- C₈H₈Cl₃N₃O₄S₂
- medical condition treated
- arterial hypertension
- canonical SMILES
- C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)NC(N2)C(Cl)Cl
- defined daily dose
- 4
- Commons category
- Trichlormethiazide
via Wikidata · CC0
~2 min read
Encyclopedic overview
3 sectionsContents
- Mechanism
- Synthesis
- References
Trichlormethiazide (INN, currently being sold under the brand names of Achletin, Diu-Hydrin and Triflumen) is a diuretic with properties similar to those of hydrochlorothiazide. It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension. In veterinary medicine, trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal limbs and general bruising.
As a diuretic (in particular a thiazide), trichlormethiazide encourages water loss from the body. Trichlormethiazide works by inhibiting Na+/Cl− ion reabsorption from the distal tubules of the kidneys. In addition, trichlormethiazide increases the excretion of potassium.
Excerpted from Wikipedia’s “trichlormethiazide” article, available under the CC BY-SA 4.0 licence.
Gallery (2)
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via Wikidata sitelinks · CC0