trametinib
Sign in to saveAlso known as TMT212, GSK1120212, GSK1120212B, GSK212, JTP 74057, Mekinist®, trametinib dimethyl sulfoxide, GSK 1120212
Trametinib, sold under the brand name Mekinist among others, is an anticancer medication used for the treatment of melanoma and glioma. It is a MEK inhibitor drug with anti-cancer activity. It inhibits MEK1 and MEK2. It is taken by mouth.
Key facts
- Drug.PubChem
- 11707110
- Drug.DrugBank
- DB08911
- Drug.image
- Trametinib.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Mekinist, Spexotras
- Drug.MedlinePlus
- a613040
- Drug.DailyMedID
- Trametinib
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- L01
- Drug.ATC_suffix
- EE01
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.CAS_number
- 871700-17-3
- Drug.ChemSpiderID
- 9881833
- Drug.UNII
- 33E86K87QN
- Drug.KEGG
- D10175
via Wikipedia infobox
Research
3,090 papers- Final Results for Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma.The New England journal of medicine · 2024
- Dabrafenib plus Trametinib in Pediatric Glioma with BRAF V600 Mutations.The New England journal of medicine · 2023
- Trametinib versus standard of care in patients with recurrent low-grade serous ovarian cancer (GOG 281/LOGS): an international, randomised, open-label, multicentre, phase 2/3 trial.Lancet (London, England) · 2022
- Trametinib.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2014
- Trametinib (GSK1120212).Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2018
via PubMed
~5 min read
Encyclopedic overview
6 sectionsContents
- Medical uses
- History
- Society and culture
- Legal status
- Research
- References
{{Infobox drug | image = Trametinib.svg | image_class = skin-invert-image | alt = | caption =
| pronounce = | tradename = Mekinist, Spexotras | Drugs.com = | MedlinePlus = a613040 | DailyMedID = Trametinib | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = By mouth | ATC_prefix = L01 | ATC_suffix = EE01
Excerpted from Wikipedia’s “trametinib” article, available under the CC BY-SA 4.0 licence.