TREM2
Sign in to saveAlso known as TREM-2, Trem2a, Trem2b, Trem2c, triggering receptor expressed on myeloid cells 2, PLOSL2
Triggering receptor expressed on myeloid cells 2 (TREM2) is a protein that in humans is encoded by the TREM2 gene. TREM2 is expressed on macrophages, immature monocyte-derived dendritic cells, osteoclasts, and microglia, which are immune cells in the central nervous system. In the liver, TREM2 is expressed by several cell types, including macrophages, that respond to injury. In the intestine, TREM2 is expressed by myeloid-derived dendritic cells and macrophage. TREM2 is overexpressed in many tumor types and has anti-inflammatory activities. It might therefore be a good therapeutic target.
Gene data
TREM2- Name
- triggering receptor expressed on myeloid cells 2
- Type
- protein-coding
- Aliases
- AD17, PLOSL2, TREM-2, Trem2a, Trem2b, Trem2c
This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012].
via MyGene.info
Gene · Ensembl
triggering receptor expressed on myeloid cells 2
- Symbol
- TREM2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:41,158,488-41,163,203
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 10352
- exact match
- identifiers.org/ncbigene/54209
- genomic end
- 41130924
- genomic start
- 41126244
- cytogenetic location
- 6p21.1
Sources (7)
via Wikidata · CC0
~12 min read
Article
15 sectionsContents
- Gene
- Structure
- Function
- Clinical significance
- Alzheimer's disease
- Cancer
- IBD
- Liver disease
- PLOSL or Nasu–Hakola disease
- Stroke
- Other diseases
- As a drug target
- Neurodegenerative diseases
- Targeting sTREM2
- References
Triggering receptor expressed on myeloid cells 2 (TREM2) is a protein that in humans is encoded by the TREM2 gene. TREM2 is expressed on macrophages, immature monocyte-derived dendritic cells, osteoclasts, and microglia, which are immune cells in the central nervous system. In the liver, TREM2 is expressed by several cell types, including macrophages, that respond to injury. In the intestine, TREM2 is expressed by myeloid-derived dendritic cells and macrophage. TREM2 is overexpressed in many tumor types and has anti-inflammatory activities. It might therefore be a good therapeutic target.
== Gene == The TREM2 gene lies on the sixth chromosome in humans, specifically in location 6p21.1. The gene has 5 coding exon regions. Alternative splicing of the TREM2 mRNA transcript leads to different isoforms of the protein being produced upon translation. Specifically, TREM2 mRNA has 3 different isoforms containing 3 consistent exons, and 2 that vary between the isoforms. TREM2 mRNA is most highly expressed in brain, lungs, adrenal glands, placenta, gall bladder, and colon. The functions of TREM2 have been studied in mice with disruption or mutation of the mouse ortholog, Trem2. TREM2 orthologs are also present in rat, dog, Rhesus monkey, macaque, chimpanzee, and other animals.