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triclosan
Sign in to saveAlso known as Stri-Dex Cleansing Bar, CH-3565, DNDI1246774, Stri-Dex Face Wash, 2,4,4'-Trichloro-2'-hydroxydiphenyl ether, 5-Chloro-2-(2,4-dichloro-phenoxy)-phenol, Triclosanum
Triclosan (sometimes abbreviated as TCS) is an antibacterial and antifungal agent present in some consumer products, including toothpaste, soaps, detergents, toys, and surgical cleaning treatments. It is similar in its uses and mechanism of action to triclocarban. Its efficacy as an antimicrobial agent, the risk of antimicrobial resistance, and its possible role in disrupted hormonal development remains controversial. Additional research seeks to understand its potential effects on organisms and environmental health.
Chemical data
- Formula
- C12H7Cl3O2
- Molecular weight
- 289.5 g/mol
- IUPAC name
- 5-chloro-2-(2,4-dichlorophenoxy)phenol
- SMILES
- C1=CC(=C(C=C1Cl)O)OC2=C(C=C(C=C2)Cl)Cl
- InChIKey
- XEFQLINVKFYRCS-UHFFFAOYSA-N
- XLogP
- 5
- Polar surface area
- 29.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Research
5,652 papers- Triclosan.Dermatitis : contact, atopic, occupational, drug · 2006
- Efficient evaluation of osteotoxicity and mechanisms of endocrine disrupting chemicals using network toxicology and molecular docking approaches: triclosan as a model compound.Ecotoxicology and environmental safety · 2025
- Triclosan: antimicrobial mechanisms, antibiotics interactions, clinical applications, and human health.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2020
- Whither triclosan?The Journal of antimicrobial chemotherapy · 2004
- Gestational triclosan exposure and infant birth weight: A systematic review and meta-analysis.Environment international · 2021
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 287.951
- Has use
- medication
Show 6 more facts
- chemical formula
- C₁₂H₇Cl₃O₂
- canonical SMILES
- C1=CC(=C(C=C1Cl)O)OC2=C(C=C(C=C2)Cl)Cl
- World Health Organisation international non-proprietary name
- triclosan
- melting point
- 57
- MCN code
- 2909.50.11
- Commons category
- Triclosan
via Wikidata · CC0
~24 min read
Encyclopedic overview
23 sectionsContents
- Uses
- Effectiveness
- Chemical structure and properties
- Synthesis
- Mechanism of action
- Endocrine disruptor
- Efflux pump inducer
- Exposure
- Distribution, metabolism, and elimination
- Health concerns
- Allergic
- By-product exposure
- Hormonal
- History
- Environmental concerns
- Treatment and disposal
- Bioaccumulation
- Ecotoxicity
- Resistance concerns
- Alternatives
- Policy
- See also
- References
Triclosan (sometimes abbreviated as TCS) is an antibacterial and antifungal agent present in some consumer products, including toothpaste, soaps, detergents, toys, and surgical cleaning treatments. It is similar in its uses and mechanism of action to triclocarban. Its efficacy as an antimicrobial agent, the risk of antimicrobial resistance, and its possible role in disrupted hormonal development remains controversial. Additional research seeks to understand its potential effects on organisms and environmental health.
Triclosan was developed in 1966. A 2006 study recommended showering with 2% triclosan as a regimen in surgical units to rid patients' skin of methicillin-resistant Staphylococcus aureus (MRSA). == Uses == Triclosan was used as a hospital scrub in the 1970s. Prior to its change in regulatory status in the EU and US, it had expanded commercially and was a common ingredient in soaps (0.10–1.00%), shampoos, deodorants, toothpastes, mouthwashes, cleaning supplies, and pesticides. It also was part of consumer products, including kitchen utensils, toys, bedding, socks, and trash bags.
Excerpted from Wikipedia’s “triclosan” article, available under the CC BY-SA 4.0 licence.