Structure via PubChem · Public domain (PubChem)
tripelennamine
Sign in to saveAlso known as Pyribenzamine®, Tripelennamina, Tripélennamine, Tripelennamin, Tripelennaminum, PBZ063
Tripelennamine, sold under the brand name Pyribenzamine by Novartis, is a drug that is used as an antipruritic and first-generation antihistamine. It can be used in the treatment of asthma, hay fever, rhinitis, and urticaria, but is now less common as it has been replaced by newer antihistamines. The drug was patented at CIBA, which merged with Geigy into Ciba-Geigy, and eventually becoming Novartis.
Chemical data
- Formula
- C16H21N3
- Molecular weight
- 255.36 g/mol
- IUPAC name
- N'-benzyl-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine
- SMILES
- CN(C)CCN(CC1=CC=CC=C1)C2=CC=CC=N2
- InChIKey
- UFLGIAIHIAPJJC-UHFFFAOYSA-N
- XLogP
- 3.3
- Polar surface area
- 19.4 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1948
- Admin. routes
- oral
- Indications
- Pruritus, allergic disease
via ChEMBL · EBI
Research
845 papersvia PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 255.173548
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₆H₂₁N₃
- World Health Organisation international non-proprietary name
- tripelennamine
- medical condition treated
- urticaria
- canonical SMILES
- CN(C)CCN(CC1=CC=CC=C1)C2=CC=CC=N2
- defined daily dose
- 0.15
- physically interacts with
- Histamine receptor H1
- Commons category
- Tripelennamine
via Wikidata · CC0
~3 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Side effects
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- History
- Society and culture
- Availability
- See also
- References
Tripelennamine, sold under the brand name Pyribenzamine by Novartis, is a drug that is used as an antipruritic and first-generation antihistamine. It can be used in the treatment of asthma, hay fever, rhinitis, and urticaria, but is now less common as it has been replaced by newer antihistamines. The drug was patented at CIBA, which merged with Geigy into Ciba-Geigy, and eventually becoming Novartis.
==Medical uses== Where and when it is/was in common use, tripelennamine is used much like other mildly-anticholinergic antihistamines to treat conditions of the upper respiratory tract arising from illnesses and hay fever. It can be used alone or in combination with other agents to have the desired effect. Cough medicines of the general formula tripelennamine + codeine/dihydrocodine/hydrocodone ± expectorant ± decongestant(s) are popular where available. Among these are the Pyribenzamine cough syrups which contain codeine, with and without decongestants, listed in the 1978 ''Physicians' Desk Reference''; the codeine-tripelennamine synergy is well-known and makes such mixtures more useful for their intended purposes.
Excerpted from Wikipedia’s “tripelennamine” article, available under the CC BY-SA 4.0 licence.
Available in 12 languages
via Wikidata sitelinks · CC0