Also known as HUPF1, NORF1, RENT1, pNORF1, smg-2, UPF1, RNA helicase and ATPase, UPF1 RNA helicase and ATPase, UTF
Regulator of nonsense transcripts 1 (or Up-frameshift suppressor 1 homolog) is a protein that in humans is encoded by the UPF1 gene.
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Biological process
Regulator of nonsense transcripts 1 (or Up-frameshift suppressor 1 homolog) is a protein that in humans is encoded by the UPF1 gene.
== Function ==
via MyGene.info
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Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).