urapidil
Sign in to saveUrapidil is a sympatholytic antihypertensive drug. It acts as an α1-adrenoceptor antagonist and as an 5-HT1A receptor agonist. Although an initial report suggested that urapidil was also an α2-adrenoceptor agonist, this was not substantiated in later studies that demonstrated it was devoid of agonist actions in the dog saphenous vein and the guinea-pig ileum. Unlike some other α1-adrenoceptor antagonists, urapidil does not elicit reflex tachycardia, and this may be related to its weak β1-adrenoceptor antagonist activity, as well as its effect on cardiac vagal drive. Urapidil is currently not a
Research
841 papers- Urapidil. A reappraisal of its use in the management of hypertension.Drugs · 1998
- Urapidil, a multiple-action alpha-blocking drug.The American journal of cardiology · 1989
- Urapidil, compared to nitroglycerin, has better clinical safety in the treatment of hypertensive patients with acute heart failure: a meta-analysis.Drug design, development and therapy · 2019
- Urapidil, a dual-acting antihypertensive agent: Current usage considerations.Advances in therapy · 2010
- [Urapidil: an unknown / known antihypertensive].Vnitrni lekarstvi · 2022
via PubMed
Wikidata facts
- Mass
- 387.227
Show 4 more facts
- chemical formula
- C₂₀H₂₉N₅O₃
- canonical SMILES
- CN1C(=CC(=O)N(C1=O)C)NCCCN2CCN(CC2)C3=CC=CC=C3OC
- Commons category
- Urapidil
- defined daily dose
- 50
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~3 min read
Article
4 sectionsContents
- Medical uses
- D/T and reperfusion injuries
- See also
- References
{{Drugbox | IUPAC_name = 6-({3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl}amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione | image = Urapidil structure.svg | image_class = skin-invert-image | width = 250px
| tradename = | Drugs.com = | pregnancy_category = | legal_status = Rx-only | routes_of_administration = Oral