Structure via PubChem · Public domain (PubChem)
vigabatrin
Sign in to saveAlso known as CPP-109, MDL-71754, Sabril®, gamma-vinyl-gamma-aminobutyric acid, gamma-vinyl GABA, GVG, 4-Amino-5-hexenoic acid, gamma-Vinyl-gamma-aminobutyric acid
Vigabatrin, sold under the brand name Vigafyde among others, is a medication used in the management and treatment of infantile spasms and refractory complex partial seizures.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 470630102
- Drug.image
- Vigabatrin.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200px
- Drug.image2
- Vigabatrin ball-and-stick.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 200px
- Drug.tradename
- Vigafyde, Sabril, others
- Drug.MedlinePlus
- a610016
- Drug.DailyMedID
- Vigabatrin
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- By mouth
- Drug.class
- Anticonvulsant; GABA-T inhibitor
- Drug.ATC_prefix
- N03
- Drug.ATC_suffix
- AG04
- Drug.legal_AU
- S4
- Drug.legal_BR
- C1
via Wikipedia infobox
Chemical data
- Formula
- C6H11NO2
- Molecular weight
- 129.16 g/mol
- IUPAC name
- 4-aminohex-5-enoic acid
- SMILES
- C=CC(CCC(=O)O)N
- InChIKey
- PJDFLNIOAUIZSL-UHFFFAOYSA-N
- XLogP
- -2.2
- Polar surface area
- 63.3 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
2,705 papers- Vigabatrin.Epilepsia · 1999
- Vigabatrin.The Annals of pharmacotherapy · 1993
- The vigabatrin-associated brain abnormalities on MRI and their differential diagnosis.Clinical radiology · 2024
- Vigabatrin.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2007
- Vigabatrin.Developmental medicine and child neurology · 2001
via PubMed
Wikidata facts
- Mass
- 129.078979
Show 5 more facts
- chemical formula
- C₆H₁₁NO₂
- canonical SMILES
- C=CC(CCC(=O)O)N
- Commons category
- Vigabatrin
- World Health Organisation international non-proprietary name
- vigabatrin
- defined daily dose
- 2
via Wikidata · CC0
~10 min read
Article
22 sectionsContents
- Medical uses
- Epilepsy
- Others
- Adverse effects
- Central nervous system
- Gastrointestinal
- Body as a whole
- Teratogenicity
- Sensory
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- History
- Society and culture
- Legal status
- Brand Names
- Research
- Solution versus powder formulation
- The PREVeNT Trial
- EPISTOP Trial
- References
Vigabatrin, sold under the brand name Vigafyde among others, is a medication used in the management and treatment of infantile spasms and refractory complex partial seizures.
It works by inhibiting the breakdown of γ-aminobutyric acid (GABA). It is also known as γ-vinyl-GABA, and is a structural analogue of GABA, but does not bind to GABA receptors.