Structure via PubChem · Public domain (PubChem)
vosilasarm
Sign in to saveAlso known as rad-140, RAD-140, 2-Chloro-4-(((1R,2S)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropyl)amino)-3-methylbenzonitrile, RAD140
Vosilasarm, also known by the development codes RAD140 and EP0062 and by the black-market name Testolone or Testalone, is a selective androgen receptor modulator (SARM) which is under development for the treatment of hormone-sensitive breast cancer. It is specifically under development for the treatment of androgen receptor-positive, estrogen receptor-negative, HER2-negative advanced breast cancer. Vosilasarm was also previously under development for the treatment of sarcopenia (age-related muscle atrophy), osteoporosis, and weight loss due to cancer cachexia, but development for these indicat
Chemical data
- Formula
- C20H16ClN5O2
- Molecular weight
- 393.8 g/mol
- IUPAC name
- 2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile
- SMILES
- CC1=C(C=CC(=C1Cl)C#N)N[C@@H](C2=NN=C(O2)C3=CC=C(C=C3)C#N)[C@H](C)O
- InChIKey
- XMBUPPIEVAFYHO-KPZWWZAWSA-N
- XLogP
- 3.1
- Polar surface area
- 119 Ų
- H-bond donors
- 2
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- breast cancer
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 393.099
Show 5 more facts
- canonical SMILES
- CC1=C(C=CC(=C1Cl)C#N)NC(C2=NN=C(O2)C3=CC=C(C=C3)C#N)C(C)O
- isomeric SMILES
- CC1=C(C=CC(=C1Cl)C#N)N[C@@H](C2=NN=C(O2)C3=CC=C(C=C3)C#N)[C@H](C)O
- chemical formula
- C₂₀H₁₆ClN₅O₂
- Commons category
- Vosilasarm
- World Health Organisation international non-proprietary name
- Vosilasarm
via Wikidata · CC0
~11 min read
Encyclopedic overview
14 sectionsContents
- Medical uses
- Side effects
- Overdose
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- History
- Society and culture
- Names
- Non-medical use
- Research
- References
- External links
{{Infobox drug | verifiedrevid = | drug_name = | type = | IUPAC_name = 2-Chloro-4-{[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino}-3-methylbenzonitrile | image = RAD140.svg | image_class = skin-invert-image | width = 250px | image2 = RAD140.png | image_class2 = bg-transparent
| tradename = | MedlinePlus = | licence_EU = | licence_US = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = By mouth
Excerpted from Wikipedia’s “vosilasarm” article, available under the CC BY-SA 4.0 licence.