WWC1
Sign in to saveAlso known as HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168, WW and C2 domain containing 1
Protein KIBRA also known as kidney and brain expressed protein (KIBRA) or WW domain-containing protein 1 (WWC1) is a protein that in humans is encoded by the WWC1 gene.
In the Vinony graph
Vinony's link graph records 6 inbound references to WWC1, and connects out to PubMed, human chromosome 5 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 5.
Vinony links it to 7 Wikipedia language editions.
Gene data
WWC1- Name
- WW and C2 domain containing 1
- Type
- protein-coding
- Position
- 168,291,563–168,472,303 (+)
- Aliases
- HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168
- Ensembl
- ENSG00000113645
- RefSeq RNA
- NM_001161661.2, NM_001161662.2, NM_015238.3, XM_005265850.2, XM_005265853.3
- RefSeq protein
- NP_001155133.1, NP_001155134.1, NP_056053.1, XP_005265907.1, XP_005265910.1
The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
WW and C2 domain containing 1
- Symbol
- WWC1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:168,291,563-168,472,303
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 69180
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/23286
- genomic end
- 167899308
- genomic start
- 168291645
- chromosome
- human chromosome 5
- cytogenetic location
- 5q34
- expressed in
- islet of Langerhans
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Research on human memory
- Interactions
- References
- Further reading
- External links
Protein KIBRA also known as kidney and brain expressed protein (KIBRA) or WW domain-containing protein 1 (WWC1) is a protein that in humans is encoded by the WWC1 gene.
== Research on human memory == A single nucleotide polymorphism (rs17070145) in the gene has been associated with human memory performance and cognitive ability in various studies since 2006. While no significant support for KIBRA's association with memory was found in a 2008 study with 584 subjects, the original 2006 study was replicated in a smaller sample of an elderly population in 2008. Two subsequent studies in 2009 in indicated that KIBRA is specifically associated with forgetting of non-semantic material as well as cognitive flexibility among smokers and non-smokers. KIBRA SNPs have been shown to increase hippocampal volume and affect spatial ability and scientific achievement.
Excerpted from Wikipedia’s “WWC1” article, available under the CC BY-SA 4.0 licence.