WWC1

Also known as HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168, WW and C2 domain containing 1

Protein KIBRA also known as kidney and brain expressed protein (KIBRA) or WW domain-containing protein 1 (WWC1) is a protein that in humans is encoded by the WWC1 gene.

Gene data

WWC1

Name: WW and C2 domain containing 1
Type: protein-coding
Position: 168,291,563–168,472,303 (+)
Aliases: HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168
Ensembl: ENSG00000113645
RefSeq RNA: NM_001161661.2, NM_001161662.2, NM_015238.3, XM_005265850.2, XM_005265853.3
RefSeq protein: NP_001155133.1, NP_001155134.1, NP_056053.1, XP_005265907.1, XP_005265910.1

The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II

~1 min read

Article

5 sections

Contents

Research on human memory
Interactions
References
Further reading
External links

Protein KIBRA also known as kidney and brain expressed protein (KIBRA) or WW domain-containing protein 1 (WWC1) is a protein that in humans is encoded by the WWC1 gene.

== Research on human memory == A single nucleotide polymorphism (rs17070145) in the gene has been associated with human memory performance and cognitive ability in various studies since 2006. While no significant support for KIBRA's association with memory was found in a 2008 study with 584 subjects, the original 2006 study was replicated in a smaller sample of an elderly population in 2008. Two subsequent studies in 2009 in indicated that KIBRA is specifically associated with forgetting of non-semantic material as well as cognitive flexibility among smokers and non-smokers. KIBRA SNPs have been shown to increase hippocampal volume and affect spatial ability and scientific achievement.