YTHDC2

Also known as CAHL, YTH domain containing 2, hYTHDC2

YTH domain containing 2 is a protein that in humans is encoded by the YTHDC2 gene.

Gene data

YTHDC2

Name: YTH N6-methyladenosine RNA binding protein C2
Type: protein-coding
Position: 113,513,694–113,595,287 (+)
Aliases: CAHL, hYTHDC2
Ensembl: ENSG00000047188
RefSeq RNA: NM_001345975.2, NM_001345976.2, NM_022828.5, XM_011543581.2, XM_011543582.3
RefSeq protein: NP_001332904.1, NP_001332905.1, NP_073739.3, XP_011541883.1, XP_011541884.1

This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line. [provided by RefSeq, Sep 2016].