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GeneQ17710289· pop 5· linked from 3 articles

Also known as ADH-5, alcohol dehydrogenase 6 (class V)

Alcohol dehydrogenase 6 is an enzyme that in humans is encoded by the ADH6 gene.

Gene data

ADH6
Name
alcohol dehydrogenase 6 (class V)
Type
protein-coding
Aliases
ADH-5

This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Gene · Ensembl

alcohol dehydrogenase 6 (class V)

Symbol
ADH6
Biotype
Protein coding
Organism
Homo sapiens
Location
4:99,202,424-99,219,537
Strand
Reverse (−)
Assembly
GRCh38
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via Ensembl · EMBL-EBI

Wikidata facts

Show 6 more facts
HomoloGene ID
68077
cytogenetic location
4q23
genomic end
100140694
genomic start
100123795
Commons category
Cinnamyl alcohol dehydrogenase, ADH6
Sources (3)

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Article

3 sections
Contents
  • References
  • Further reading
  • External links

Alcohol dehydrogenase 6 is an enzyme that in humans is encoded by the ADH6 gene.

This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. The deduced amino acid sequence of the open reading frame of this gene shows about 60% positional identity with other known alcohol dehydrogenases. This gene may have a distinct physiologic function.

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