agrin
Sign in to saveAlso known as agrin proteoglycan, uniprot:O00468, AGRN
Agrin is a large proteoglycan whose best-characterised role is in the development of the neuromuscular junction during embryogenesis. Agrin is named based on its involvement in the aggregation of acetylcholine receptors during synaptogenesis. In humans, this protein is encoded by the AGRN gene.
Protein · UniProt
Agrin
- Gene
- AGRN
- Organism
- Homo sapiens (Human)
- Length
- 2,068 aa
- Molecular mass
- 217,320 Da
- Evidence
- 1: Evidence at protein level
Depending on alternative splicing and post-translational modifications, it has a role in different processes, including neuromuscular junction formation and maintenance, and regulation of neurite outgrowth (By similarity). Also involved in positive regulation of cartilage formation through alpha-dystroglycan binding and up-regulation of SOX9 (PubMed:26290588)
Swiss-Prot (reviewed) · via UniProt
Research
1,584 papers- The agrin hypothesis.Cold Spring Harbor symposia on quantitative biology · 1990
- Agrin and LRP4 antibodies as new biomarkers of myasthenia gravis.Annals of the New York Academy of Sciences · 2018
- Role of Agrin in tissue repair and regeneration: From mechanisms to therapeutic opportunities (Review).International journal of molecular medicine · 2024
- Agrin-like proteins of the neuromuscular junction.Neurochemistry international · 1994
- An Agrin-YAP/TAZ Rigidity Sensing Module Drives EGFR-Addicted Lung Tumorigenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
via PubMed
Clinical Trials
2 registered- UNKNOWNThe Role of the Muscle-nervous System Interface in Cancer CachexiaUniversity of Roma La Sapienza · NCT03477721
- COMPLETEDEvaluation of CAF22 After Renal TransplantationInsel Gruppe AG, University Hospital Bern · NCT02346968
Wikidata facts
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- Commons category
- Agrin
via Wikidata · CC0
~5 min read
Article
10 sectionsContents
- Discovery
- Mechanism of action
- Signaling
- Structure
- Functions
- Research
- Clinical significance
- References
- Further reading
- External links
Agrin is a large proteoglycan whose best-characterised role is in the development of the neuromuscular junction during embryogenesis. Agrin is named based on its involvement in the aggregation of acetylcholine receptors during synaptogenesis. In humans, this protein is encoded by the AGRN gene.
This protein has nine domains homologous to protease inhibitors. It may also have functions in other tissues and during other stages of development. It is a major proteoglycan component in the glomerular basement membrane and may play a role in the renal filtration and cell-matrix interactions.