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Synuclein alpha
Sign in to saveAlso known as synuclein, alpha (non A4 component of amyloid precursor), synuclein alpha-140, truncated alpha synuclein, Non-A4 component of amyloid precursor, SNCA, Non-A beta component of AD amyloid, non A-beta component of AD amyloid, alpha-synuclein
Alpha-synuclein (aSyn) is a protein that in humans is encoded by the SNCA gene. It is a neuronal protein involved in the regulation of synaptic vesicle trafficking and the release of neurotransmitters.
Protein · UniProt
Alpha-synuclein
- Gene
- SNCA
- Organism
- Homo sapiens (Human)
- Length
- 140 aa
- Molecular mass
- 14,460 Da
- Evidence
- 1: Evidence at protein level
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:20798282, PubMed:26442590, PubMed:28288128, PubMed:30404828). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Also acts as a molecular chaperone in its mu…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
52 registered- UNKNOWNBiomarker Analysis for GBA Associated Parkinson's DiseaseLysosomal and Rare Disorders Research and Treatment Center, Inc. · NCT03811496
- PHASE1COMPLETEDA First-in-Human Study of Single and Multiple Doses of anle138b in Healthy SubjectsMODAG GmbH · NCT04208152
- COMPLETEDCutaneous Autonomic Pilomotor Testing to Unveil the Role of Neuropathy Progression in Early Parkinson's DiseaseGWT-TUD GmbH · NCT03043768
- UNKNOWNBiomarkers in Parkinsonian SyndromesUniversity Hospital, Bordeaux · NCT02114242
- EARLY_PHASE1RECRUITINGStudy of Biodistribution, Metabolism, Excretion and Brain Uptake of 11C-HY-2-15University of Pennsylvania · NCT06032026
- RECRUITINGColonoscopic Detection of Phosphorylated Alpha-synuclein for Parkinson's DiagnosisCND Life Sciences · NCT07204652
Wikidata facts
Show 2 more facts
- Commons category
- Alpha-synuclein
- exact match
- purl.uniprot.org/uniprot/P37840
via Wikidata · CC0
~24 min read
Article
14 sectionsContents
- Tissue expression
- In the enteric nervous system (ENS)
- Structure
- Interaction with lipid membranes
- Function
- Proneurogenic function of alpha-synuclein
- Sequence
- Autoproteolytic activity
- Clinical significance
- Protein-protein interactions
- See also
- References
- Further reading
- External links
Alpha-synuclein (aSyn) is a protein that in humans is encoded by the SNCA gene. It is a neuronal protein involved in the regulation of synaptic vesicle trafficking and the release of neurotransmitters.
Alpha-synuclein is abundant in the brain, with smaller amounts present in the heart, muscles, and other tissues. Within the brain, it is primarily localized to the axon terminals of presynaptic neurons. There, it interacts with phospholipids and other proteins. Presynaptic terminals release neurotransmitters from specialized compartments called synaptic vesicles, a process essential for neuronal communication and normal brain function.