알파-시누클레인

Also known as synuclein, alpha (non A4 component of amyloid precursor), synuclein alpha-140, truncated alpha synuclein, Non-A4 component of amyloid precursor, SNCA, Non-A beta component of AD amyloid, non A-beta component of AD amyloid, alpha-synuclein

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In the Vinony graph

Within Vinony's link graph, 알파-시누클레인 is referenced by 157 other articles, and connects out to synaptic vesicle, amino acid and plasma membrane.

Vinony files it under Genes on human chromosome 4, Lewy body dementia and Membrane channels.

Its subject is documented across 19 Wikipedia language editions.

Protein · UniProt

Alpha-synuclein

Gene: SNCA
Organism: Homo sapiens (Human)
Length: 140 aa
Molecular mass: 14,460 Da
Evidence: 1: Evidence at protein level

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:20798282, PubMed:26442590, PubMed:28288128, PubMed:30404828). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Also acts as a molecular chaperone in its mu…

3D-structureAcetylationAlternative splicingAlzheimer diseaseAmyloidCell projectionCopperCytoplasm

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Swiss-Prot (reviewed) · via UniProt