SNCAIP

Also known as SYPH1, Sph1, synuclein alpha interacting protein

Synphilin-1 is a protein that in humans is encoded by the SNCAIP gene. SNCAIP stands for "synuclein, alpha interacting protein".

Gene data

SNCAIP

Name: synuclein alpha interacting protein
Type: protein-coding
Position: 122,311,354–122,464,224 (+)
Aliases: SYPH1, Sph1
Ensembl: ENSG00000064692
RefSeq RNA: NM_001242935.3, NM_001308100.2, NM_001308105.1, NM_001308106.1, NM_001308107.2
RefSeq protein: NP_001229864.1, NP_001295029.1, NP_001295034.1, NP_001295035.1, NP_001295036.1

This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].

Gene Ontology

Biological process

cell death

Article

7 sections

Contents

Structure
Function
Ubiquitination
Clinical significance
Interactions
References
Further reading

Synphilin-1 is a protein that in humans is encoded by the SNCAIP gene. SNCAIP stands for "synuclein, alpha interacting protein".

Synphilin-1 is a cytosolic protein first identified in 1999 as a novel binding partner of α-synuclein, localized within Lewy bodies in Parkinson's disease brain tissue. Experimental studies in mammalian cells and yeast demonstrated that co-expression of synphilin-1 with α-synuclein promotes the formation of cytoplasmic inclusions resembling Lewy bodies.