SNCB
Sign in to saveAlso known as entrez:6620, synuclein beta
Beta-synuclein is a protein that in humans is encoded by the SNCB gene.
Gene data
SNCB- Name
- synuclein beta
- Type
- protein-coding
- Position
- 176,620,082–176,630,672 (−)
- Ensembl
- ENSG00000074317
- RefSeq RNA
- NM_001001502.3, NM_001318034.2, NM_001318035.2, NM_001318036.2, NM_001318037.2
- RefSeq protein
- NP_001001502.1, NP_001304963.1, NP_001304964.1, NP_001304965.1, NP_001304966.1
This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
synuclein beta
- Symbol
- SNCB
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:176,620,082-176,630,672
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 2320
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6620
- genomic end
- 176057530
- genomic start
- 176620082
- chromosome
- human chromosome 5
- cytogenetic location
- 5q35.2
- expressed in
- hypothalamus
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- See also
- References
- Further reading
- External links
Beta-synuclein is a protein that in humans is encoded by the SNCB gene.
The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer's disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson's disease; however, no direct relation to Parkinson's disease has been established. Two transcript variants encoding the same protein have been found for this gene.
Excerpted from Wikipedia’s “SNCB” article, available under the CC BY-SA 4.0 licence.