SNCB

Also known as entrez:6620, synuclein beta

Beta-synuclein is a protein that in humans is encoded by the SNCB gene.

Gene data

SNCB

Name: synuclein beta
Type: protein-coding
Position: 176,620,082–176,630,672 (−)
Ensembl: ENSG00000074317
RefSeq RNA: NM_001001502.3, NM_001318034.2, NM_001318035.2, NM_001318036.2, NM_001318037.2
RefSeq protein: NP_001001502.1, NP_001304963.1, NP_001304964.1, NP_001304965.1, NP_001304966.1

This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].

Gene Ontology

Biological process

chemical synaptic transmission synaptic vesicle endocytosis synaptic vesicle endocytosis

Article

4 sections

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See also
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External links

Beta-synuclein is a protein that in humans is encoded by the SNCB gene.

The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer's disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson's disease; however, no direct relation to Parkinson's disease has been established. Two transcript variants encoding the same protein have been found for this gene.