SNCB

Also known as entrez:6620, synuclein beta

Beta-synuclein is a protein that in humans is encoded by the SNCB gene.

Gene data

SNCB

Name: synuclein beta
Type: protein-coding
Position: 176,620,082–176,630,672 (−)
Ensembl: ENSG00000074317
RefSeq RNA: NM_001001502.3, NM_001318034.2, NM_001318035.2, NM_001318036.2, NM_001318037.2
RefSeq protein: NP_001001502.1, NP_001304963.1, NP_001304964.1, NP_001304965.1, NP_001304966.1

This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].

Gene Ontology

Biological process

chemical synaptic transmission synaptic vesicle endocytosis synaptic vesicle endocytosis synapse organization

Molecular function

phospholipase inhibitor activity calcium ion binding protein binding transition metal ion binding cuprous ion binding cuprous ion binding cuprous ion binding

Cellular component

cytoplasm cytoplasm cytosol inclusion body inclusion body neuronal cell body axon terminus synapse

Pathways

MTF1 activates gene expression Response to metal ions Cellular responses to stimuli

via MyGene.info

Gene · Ensembl

synuclein beta

Symbol: SNCB
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:176,620,082-176,630,672
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 2320
exact match: identifiers.org/ncbigene/6620
genomic end: 176057530
genomic start: 176620082
cytogenetic location: 5q35.2

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Beta-synuclein is a protein that in humans is encoded by the SNCB gene.

The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer's disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson's disease; however, no direct relation to Parkinson's disease has been established. Two transcript variants encoding the same protein have been found for this gene.