SCG5

Also known as 7B2, P7B2, SGNE1, SgV, secretogranin V

Neuroendocrine protein 7B2 is a protein that in humans is encoded by the SCG5 gene. The protein expressed by this gene is widely distributed in neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 by blocking the aggregation of this protein, and is required for the production of an active PC2 enzyme. It is an intrinsically disordered protein that may also function as a chaperone for other aggregating secretory proteins in addition to proPC2 (Helwig et al. 2013). 7B2 has been identified in vertebrates and in invertebrates as low as flatworms (Protein ID:

Gene data

SCG5

Name: secretogranin V
Type: protein-coding
Position: 32,641,385–32,697,098 (+)
Aliases: 7B2, P7B2, SGNE1, SgV
Ensembl: ENSG00000166922
RefSeq RNA: NM_001144757.3, NM_001394278.1, NM_001394279.1, NM_003020.5
RefSeq protein: NP_001138229.1, NP_001381207.1, NP_001381208.1, NP_003011.1

This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and metabolic disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019].