AKR1C1
Sign in to saveAlso known as 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37
Aldo-keto reductase family 1 member C1 also known as 20α-hydroxysteroid dehydrogenase, 3α-hydroxysteroid dehydrogenase, and dihydrodiol dehydrogenase 1/2 is an enzyme that in humans is encoded by the AKR1C1 gene.
In the Vinony graph
Vinony's link graph records 443 inbound references to AKR1C1, and connects out to PubMed, human chromosome 10 and Ensembl genome database project.
Vinony files it under EC 1.1.1 and Genes on human chromosome 10.
Vinony links it to 5 Wikipedia language editions.
Gene data
AKR1C1- Name
- aldo-keto reductase family 1 member C1
- Type
- protein-coding
- Position
- 4,944,110–4,983,283 (+)
- Aliases
- 2-ALPHA-HSD, 20-ALPHA-HSD, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB
- Ensembl
- ENSG00000187134
- RefSeq RNA
- NM_001353.6
- RefSeq protein
- NP_001344.2
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
aldo-keto reductase family 1 member C1
- Symbol
- AKR1C1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:4,944,110-4,983,283
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein AKR1C1 PDB 1ihi.png
Show 8 more facts
- HomoloGene ID
- 134114
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1645
- chromosome
- human chromosome 10
- genomic start
- 4934796
- genomic end
- 5025475
- cytogenetic location
- 10p15.1
- expressed in
- gallbladder
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Superfamily of enzymes
- Isozymes of aldo-keto reductase family 1 member C
- References
- See also
- External links
- Further reading
Aldo-keto reductase family 1 member C1 also known as 20α-hydroxysteroid dehydrogenase, 3α-hydroxysteroid dehydrogenase, and dihydrodiol dehydrogenase 1/2 is an enzyme that in humans is encoded by the AKR1C1 gene.
==Superfamily of enzymes== This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This specific enzyme, AKR1C1, among other reactions, catalyzes the reduction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. The AKR1C1 gene shares high sequence identity with three other gene members, and is clustered with those three genes at chromosome 10p15-p14.
Excerpted from Wikipedia’s “AKR1C1” article, available under the CC BY-SA 4.0 licence.