ALAD

Also known as ALADH, PBGS, aminolevulinate dehydratase, ALA dehydratase

protein-coding gene in the species Homo sapiens

Gene data

ALAD

Name: aminolevulinate dehydratase
Type: protein-coding
Aliases: ALADH, PBGS

The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].

via MyGene.info