Ferrochelatase
Sign in to saveAlso known as heme synthase, ferrochelatase, mitochondrial, heme synthetase, FECH, protoheme ferro-lyase, protoporphyria
Protoporphyrin ferrochelatase (EC 4.98.1.1, formerly EC 4.99.1.1, or ferrochelatase; systematic name protoheme ferro-lyase (protoporphyrin-forming)) is an enzyme encoded by the FECH gene in humans. Ferrochelatase catalyses the eighth and terminal step in the biosynthesis of heme, converting protoporphyrin IX into heme B. It catalyses the reaction:
Key facts
- Enzyme.align
- right
- Enzyme.name
- Protoporphyrin ferrochelatase
- Enzyme.image
- 1hrk.jpg
- Enzyme.image_size
- 270
- Enzyme.caption
- Ferrochelatase homodimer, Human
- Enzyme.EC_number
- 4.98.1.1
- Enzyme.CAS_number
- 9012-93-5
- Enzyme.GO_code
- 0004325
via Wikipedia infobox
Protein · UniProt
Ferrochelatase, mitochondrial
- Gene
- FECH
- Organism
- Homo sapiens (Human)
- Length
- 423 aa
- Molecular mass
- 47,862 Da
- Evidence
- 1: Evidence at protein level
Catalyzes the ferrous insertion into protoporphyrin IX and participates in the terminal step in the heme biosynthetic pathway
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
30 registered- RECRUITINGLongitudinal Study of the PorphyriasThe American Porphyrias Expert Collaborative · NCT01561157
- NACOMPLETEDOral Iron for Erythropoietic ProtoporphyriasIcahn School of Medicine at Mount Sinai · NCT02979249
- PHASE3COMPLETEDMulticentre Phase III Erythropoietic Protoporphyria StudyClinuvel Pharmaceuticals Limited · NCT04053270
- PHASE2ENROLLING_BY_INVITATIONGATEWAY: A Phase 2a Study of PORT-77 in Adults With Erythropoietic ProtoporphyriaPortal Therapeutics, Inc. · NCT06971900
- COMPLETEDErythropoietic Protoporphyrias: Studies of the Natural History, Genotype-Phenotype Correlations, and Psychosocial ImpactIcahn School of Medicine at Mount Sinai · NCT01688895
- TEMPORARILY_NOT_AVAILABLEExpanded Access Program of Bitopertin For Participants With EPP or XLPDisc Medicine, Inc · NCT07603401
Wikidata facts
- Instance of
- protein
Show 3 more facts
- exact match
- purl.uniprot.org/uniprot/P22830
- cell component
- mitochondrion
- found in taxon
- Homo sapiens
via Wikidata · CC0
~6 min read
Encyclopedic overview
9 sectionsContents
- Function
- Structure
- Mechanism
- Clinical significance
- Interactions
- See also
- References
- Further reading
- External links
Protoporphyrin ferrochelatase (EC 4.98.1.1, formerly EC 4.99.1.1, or ferrochelatase; systematic name protoheme ferro-lyase (protoporphyrin-forming)) is an enzyme encoded by the FECH gene in humans. Ferrochelatase catalyses the eighth and terminal step in the biosynthesis of heme, converting protoporphyrin IX into heme B. It catalyses the reaction:
== Function ==
Excerpted from Wikipedia’s “Ferrochelatase” article, available under the CC BY-SA 4.0 licence.