ankyrin
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Ankyrins are a family of proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane cytoskeleton. Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers and ion transporters in the plasma membrane. The name is derived from the Greek word ἄγκυρα (ankyra) for "anchor".
Key facts
- Protein.Band
- 21
- Protein.Name
- ANK3, node of Ranvier
- Protein.caption
- Ribbon diagram of a fragment of the membrane-binding domain of ankyrin R.
- Protein.image
- Ankyrin R membrane-binding domain 1N11.png
- Protein.width
- 250
- Protein.HGNCid
- 494
- Protein.Symbol
- ANK3
- Protein.AltSymbols
- AnkyrinG
- Protein.EntrezGene
- 288
- Protein.OMIM
- 600465
- Protein.RefSeq
- NM_020987
- Protein.UniProt
- Q12955
- Protein.PDB
- 1N11
- Protein.Chromosome
- 10
- Protein.Arm
- q
- Protein.LocusSupplementaryData
- -q27
via Wikipedia infobox
Research
7,586 papers- Architecture of the human erythrocyte ankyrin-1 complex.Nature structural & molecular biology · 2022
- Roles and mechanisms of ankyrin-G in neuropsychiatric disorders.Experimental & molecular medicine · 2022
- Ankyrin-G and Its Binding Partners in Neurons: Orchestrating the Molecular Structure of the Axon Initial Segment.Biomolecules · 2025
- Ankyrin-B modulates mitochondrial fission in skeletal muscle and is required for optimal endurance exercise capacity.Nature communications · 2025
- Signaling Size: Ankyrin and SOCS Box-Containing ASB E3 Ligases in Action.Trends in biochemical sciences · 2019
via PubMed
Wikidata facts
- Image
- PDB 1n11 EBI.jpg
Show 1 more fact
- Commons category
- Ankyrin
Sources (2)
via Wikidata · CC0
~3 min read
Article
9 sectionsContents
- Structure
- Membrane protein recognition
- Subtypes
- ANK1
- ANK2
- ANK3
- See also
- References
- External links
Ankyrins are a family of proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane cytoskeleton. Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers and ion transporters in the plasma membrane. The name is derived from the Greek word ἄγκυρα (ankyra) for "anchor".
==Structure== Ankyrins contain four functional domains: an N-terminal domain that contains 24 tandem ankyrin repeats, a central domain that binds to spectrin, a death domain that binds to proteins involved in apoptosis, and a C-terminal regulatory domain that is highly variable between different ankyrin proteins.