ARHGEF12
Sign in to saveAlso known as LARG, PRO2792, Rho guanine nucleotide exchange factor 12
Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene. This protein is also called RhoGEF12 or Leukemia-associated Rho guanine nucleotide exchange factor (LARG).
Gene data
ARHGEF12- Name
- Rho guanine nucleotide exchange factor 12
- Type
- protein-coding
- Aliases
- LARG, PRO2792
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].
via MyGene.info
Gene · Ensembl
Rho guanine nucleotide exchange factor 12
- Symbol
- ARHGEF12
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:120,336,238-120,489,937
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~2 min read
Encyclopedic overview
7 sectionsContents
- Function
- Clinical significance
- Interactions
- See also
- References
- Further reading
- External links
Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene. This protein is also called RhoGEF12 or Leukemia-associated Rho guanine nucleotide exchange factor (LARG).
== Function == Rho guanine nucleotide exchange factor 12 is guanine nucleotide exchange factor (GEF) for the RhoA small GTPase protein. Rho is a small GTPase protein that is inactive when bound to the guanine nucleotide GDP. But when acted on by Rho GEF proteins such as RhoGEF1, this GDP is released and replaced by GTP, leading to the active state of Rho. In this active, GTP-bound conformation, Rho can bind to and activate specific effector proteins and enzymes to regulate cellular functions. In particular, active Rho is a major regulator of the cell actin cytoskeleton.
Excerpted from Wikipedia’s “ARHGEF12” article, available under the CC BY-SA 4.0 licence.