atropine

Also known as (+-)-Hyoscyamine, (+,-)-Tropyl tropate, dl-tropyltropate, Mydriasine, (3-Endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate, (±)-hyoscyamine, Tropine tropate, (+-)-Atropine

Atropine is a tropane alkaloid and anticholinergic medication used to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate, and to decrease saliva production during surgery. It is typically given intravenously or by injection into a muscle. Eye drops are also available which are used to treat uveitis and early amblyopia. The intravenous solution usually begins working within a minute and lasts half an hour to an hour. Large doses may be required to treat some poisonings.

AI overview

Atropine is a medication that blocks certain nerve signals in the body, and it's used to treat poisonings from nerve agents or pesticides, manage abnormally slow heart rates, reduce saliva during surgery, and treat certain eye conditions. It's typically given by injection or intravenous infusion and works quickly—often within a minute—though doctors may need to give large doses in poisoning cases.

AI-generated from the Wikipedia summary — may contain errors.

Chemical data

Formula: C17H23NO3
Molecular weight: 289.4 g/mol
IUPAC name: [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate
SMILES: CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
InChIKey: RKUNBYITZUJHSG-PJPHBNEVSA-N
XLogP: 1.8
Polar surface area: 49.8 Å²
H-bond donors: 1
H-bond acceptors: 4
Formal charge: 0

via PubChem

Research

43,943 papers

[Atropine].Krankenpflege Journal · 1987Blumenberg D
[Atropine].Ugeskrift for laeger · 1994Hagelsten JO
[ATROPINE AND SCOPOLAMINE].ReviewDer Anaesthesist · 1965LIST WF, GRAVENSTEIN JS
Atropine: animal models.Annals of emergency medicine · 1984Rosborough JPDOI: 10.1016/s0196-0644(84)80446-1
The metabolism of atropine in man.The Journal of pharmacy and pharmacology · 1986Van der Meer MJ, Hundt HK, Müller FODOI: 10.1111/j.2042-7158.1986.tb04494.x
[Indication for preoperative administration of atropine].ReviewUgeskrift for laeger · 1980Bendtsen A
Atropine maintenance dosage in patients with severe organophosphate pesticide poisoning.Toxicology letters · 2011Thiermann H, Steinritz D, Worek F et al.DOI: 10.1016/j.toxlet.2011.07.006
Safety of DIMS Spectacle Lenses and Atropine as Combination Therapy for Myopia Progression.Klinische Monatsblatter fur Augenheilkunde · 2022Kaymak H, Mattern AI, Graff B et al.DOI: 10.1055/a-1930-7116

via PubMed

Wikidata facts

Mass: 289.4
Image: Atropine injection ampoule.JPG

Show 4 more facts

Commons category: Atropine
World Health Organisation international non-proprietary name: atropine
chemical formula: C₁₇H₂₃NO₃
defined daily dose: 1.5

Sources (6)

via Wikidata · CC0

~17 min read

Article

18 sections

Contents

Medical uses
Eyes
Heart
Secretions
Poisonings
Irinotecan-induced diarrhea
Contraindications
Side effects
Pharmacology
Chemistry
Synthesis
Natural sources
Biosynthesis
History
Society and culture
Legal status
References
External links

Common side effects include dry mouth, abnormally large pupils, urinary retention, constipation, and a fast heart rate. It should generally not be used in people with closed-angle glaucoma. While there is no evidence that its use during pregnancy causes birth defects, this has not been well studied so sound clinical judgment should be used. It is likely safe during breastfeeding. It is an antimuscarinic (a type of anticholinergic) that works by inhibiting the parasympathetic nervous system.