azlocillin
Sign in to saveAlso known as (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-{[(2R)-2-{[(2-oxoimidazolidin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 2,2-dimethyl-6beta-[(2R)-2-{[(2-oxoimidazolidin-1-yl)carbonyl]amino}-2-phenylacetamido]penam-3alpha-carboxylic acid, Azlocilina, Azlocilline, Azlocillinum
Azlocillin is an acyl ampicillin antibiotic with an extended spectrum of activity and greater in vitro potency than the carboxy penicillins. Azlocillin is similar to mezlocillin and piperacillin. It demonstrates antibacterial activity against a broad spectrum of bacteria, including Pseudomonas aeruginosa, and, in contrast to most cephalosporins, exhibits activity against enterococci.
Research
775 papers- Azlocillin.Drug and therapeutics bulletin · 1981
- Azlocillin, mezlocillin, and piperacillin: new broad-spectrum penicillins.Annals of internal medicine · 1982
- [Azlocillin pharmacokinetics].Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] · 1988
- The acylampicillins: mezlocillin, piperacillin, and azlocillin.Reviews of infectious diseases · 1984
- Population pharmacokinetics and dosing optimization of azlocillin in neonates with early-onset sepsis: a real-world study.The Journal of antimicrobial chemotherapy · 2021
via PubMed
Wikidata facts
- Mass
- 461.136904
Show 6 more facts
- chemical formula
- C₂₀H₂₃N₅O₆S
- Commons category
- Azlocillin
- World Health Organisation international non-proprietary name
- azlocillin
- isomeric SMILES
- CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)NC(=O)N4CCNC4=O)C(=O)O)C
- canonical SMILES
- CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)NC(=O)N4CCNC4=O)C(=O)O)C
- defined daily dose
- 12
Sources (6)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Spectrum of bacterial susceptibility
- Synthesis
- See also
- References
Azlocillin is an acyl ampicillin antibiotic with an extended spectrum of activity and greater in vitro potency than the carboxy penicillins. Azlocillin is similar to mezlocillin and piperacillin. It demonstrates antibacterial activity against a broad spectrum of bacteria, including Pseudomonas aeruginosa, and, in contrast to most cephalosporins, exhibits activity against enterococci.
== Spectrum of bacterial susceptibility == Azlocillin is considered a broad spectrum antibiotic and can be used against a number of Gram positive and Gram negative bacteria. The following represents MIC susceptibility data for a few medically significant organisms. Escherichia coli 1 μg/mL – 32 μg/mL Haemophilus spp. 0.03 μg/mL – 2 μg/mL Pseudomonas aeruginosa 4 μg/mL – 6.25 μg/mL