Structure via PubChem · Public domain (PubChem)
benzydamine
Sign in to saveAlso known as 1-benzyl-3-[3-(dimethylamino)propoxy]-1H-indazole
thumb|Benzydamine medicinal mouthwash as sold in Argentina. Benzydamine (also known as Tantum Verde and branded in some countries as Maxtra Gargle, Difflam and Septabene), available as the hydrochloride salt, is a locally acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions of the mouth and throat. It falls under class of chemicals known as indazoles.
In the Vinony graph
Vinony's link graph records 1,829 inbound references to benzydamine, and connects out to cannabinoids, dentistry and lysergic acid diethylamide.
It sits within the topics Aromatic ethers, Benzyl compounds and Chemical pages without DrugBank identifier.
Vinony links it to 24 Wikipedia language editions.
Key facts
- Drug.verifiedrevid
- 414278352
- Drug.IUPAC_name
- 3-(1-benzyl-1H-indazol-3-yloxy)-N,N-dimethylpropan-1-amine
- Drug.image
- Benzydamine-2D-skeletal.png
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Maxtra Gargle, Difflam, Tantum verde
- Drug.pregnancy_AU
- B2
- Drug.routes_of_administration
- Oral, topical
- Drug.legal_AU
- S4
- Drug.legal_AU_comment
- /Schedule 2
- Drug.legal_BR
- C1
- Drug.legal_UK
- P and POM
- Drug.legal_EU
- OTC
- Drug.protein_bound
- <20%
- Drug.elimination_half life
- 13 hours
- Drug.excretion
- Kidney
- Drug.CAS_number
- 642-72-8
- Drug.ATC_prefix
- A01
- Drug.ATC_suffix
- AD02
via Wikipedia infobox
Chemical data
- Formula
- C19H23N3O
- Molecular weight
- 309.4 g/mol
- IUPAC name
- 3-(1-benzylindazol-3-yl)oxy-N,N-dimethylpropan-1-amine
- SMILES
- CN(C)CCCOC1=NN(C2=CC=CC=C21)CC3=CC=CC=C3
- InChIKey
- CNBGNNVCVSKAQZ-UHFFFAOYSA-N
- XLogP
- 3.9
- Polar surface area
- 30.3 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- rheumatic disease, vaginal inflammation, Arthralgia, Myalgia
via ChEMBL · EBI
Research
693 papers- Benzydamine hydrochloride: an overview on a well-established drug with news in mechanisms of action.F1000Research · 2024
- Benzydamine-An Affordable Over-the-Counter Drug with Psychoactive Properties-From Chemical Structure to Possible Pharmacological Properties.Pharmaceuticals (Basel, Switzerland) · 2023
- The Benzydamine Experience: A Systematic Review of Benzydamine Abuse.Current neuropharmacology · 2021
- PMID 308307322018
- PMID 308557692018
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Has part
- oxygen
- Mass
- 309.184112
- Has use
- medication
Show 8 more facts
- chemical formula
- C₁₉H₂₃N₃O
- World Health Organisation international non-proprietary name
- benzydamine
- defined daily dose
- 9
- canonical SMILES
- CN(C)CCCOC1=NN(C2=CC=CC=C21)CC3=CC=CC=C3
- Commons category
- Benzydamine
- subject has role
- non-steroidal anti-inflammatory drug
- medical condition treated
- pharyngitis
- melting point
- 320
via Wikidata · CC0
~5 min read
Encyclopedic overview
12 sectionsContents
- History
- Uses
- Medical
- Recreational
- Contraindications
- Side effects
- Pharmacology
- Pharmacokinetic
- Synthesis
- Research
- References
- External links
thumb|Benzydamine medicinal mouthwash as sold in Argentina. Benzydamine (also known as Tantum Verde and branded in some countries as Maxtra Gargle, Difflam and Septabene), available as the hydrochloride salt, is a locally acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions of the mouth and throat. It falls under class of chemicals known as indazoles.
==History== It was synthesized in Italy in 1964 and marketed in 1966.
Excerpted from Wikipedia’s “benzydamine” article, available under the CC BY-SA 4.0 licence.