BRD8

Also known as SMAP, SMAP2, p120, bromodomain containing 8

Bromodomain-containing protein 8 is a protein that in humans is encoded by the BRD8 gene.

Gene data

BRD8

Name: bromodomain containing 8
Type: protein-coding
Position: 138,139,770–138,178,953 (−)
Aliases: SMAP, SMAP2, p120
Ensembl: ENSG00000112983
RefSeq RNA: NM_001164326.2, NM_001300961.3, NM_001300962.3, NM_001300966.3, NM_006696.5
RefSeq protein: NP_001157798.1, NP_001287890.1, NP_001287891.1, NP_001287895.1, NP_006687.3

The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Multiple alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2014].

Gene Ontology

Biological process

cell surface receptor signaling pathway regulation of apoptotic process positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of cell cycle cellular response to thyroid hormone stimulus positive regulation of double-strand break repair via homologous recombination

Molecular function

transcription coactivator activity protein binding nuclear thyroid hormone receptor binding

Cellular component

Swr1 complex nucleus nucleus nucleoplasm nucleoplasm NuA4 histone acetyltransferase complex NuA4 histone acetyltransferase complex

Pathways

HATs acetylate histones Chromatin modifying enzymes Chromatin organization

via MyGene.info

Gene · Ensembl

bromodomain containing 8

Symbol: BRD8
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:138,139,770-138,178,988
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 41790
exact match: identifiers.org/ncbigene/10902
genomic end: 138178953
genomic start: 138139770
cytogenetic location: 5q31.2

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Bromodomain-containing protein 8 is a protein that in humans is encoded by the BRD8 gene.

The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified.