THRB

Name

thyroid hormone receptor beta

Type

protein-coding

Position

24,117,153–24,495,756 (−)

Aliases

C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2, THRbeta

Ensembl

ENSG00000151090

RefSeq RNA

NM_000461.5, NM_001128176.3, NM_001128177.2, NM_001252634.2, NM_001354708.2

RefSeq protein

NP_000452.2, NP_001121648.1, NP_001121649.1, NP_001239563.1, NP_001341637.1

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

thyroid hormone receptor beta

Symbol

THRB

Biotype

Protein coding

Organism

Homo sapiens

Location

3:24,117,153-24,495,756

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

Protein THRB PDB 1bsx.png

via Wikidata · CC0