THBS1
Sign in to saveAlso known as THBS, THBS-1, TSP, TSP-1, TSP1, thrombospondin 1
protein-coding gene in the species Homo sapiens
Gene data
THBS1- Name
- thrombospondin 1
- Type
- protein-coding
- Position
- 39,580,130–39,599,466 (+)
- Aliases
- THBS, THBS-1, TSP, TSP-1, TSP1
- Ensembl
- ENSG00000137801
- RefSeq RNA
- NM_003246.4, XM_011521971.3, XM_047432980.1, XM_054378685.1, XM_054378686.1
- RefSeq protein
- NP_003237.2, XP_011520273.1, XP_047288936.1, XP_054234660.1, XP_054234661.1
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
response to hypoxianegative regulation of endothelial cell proliferationnegative regulation of endothelial cell proliferationnegative regulation of endothelial cell proliferationnegative regulation of endothelial cell proliferationnegative regulation of cell-matrix adhesionnegative regulation of cell-matrix adhesionsprouting angiogenesis
Molecular function
Pathways
Rap1 signaling pathway - Homo sapiens (human)p53 signaling pathway - Homo sapiens (human)Phagosome - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)TGF-beta signaling pathway - Homo sapiens (human)Focal adhesion - Homo sapiens (human)ECM-receptor interaction - Homo sapiens (human)Malaria - Homo sapiens (human)Human papillomavirus infection - Homo sapiens (human)Proteoglycans in cancer - Homo sapiens (human)
via MyGene.info
Gene · Ensembl
thrombospondin 1
- Symbol
- THBS1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:39,580,130-39,599,466
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein THBS1 PDB 1lsl.png
Show 6 more facts
- HomoloGene ID
- 31142
- exact match
- identifiers.org/ncbigene/7057
- genomic end
- 39891667
- genomic start
- 39873280
- cytogenetic location
- 15q14
- Commons category
- Thrombospondin-1
via Wikidata · CC0
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