File:Propranolol_structure.svg · Wikimedia Commons · See Wikimedia Commons
propranolol
Sign in to saveAlso known as propranolol hydrochloride, Propanolol, 1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol, beta-Propranolol, 1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol, Propanalol, Euprovasin, [2-hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine
Propranolol is a medication of the beta blocker class. It is used to treat high blood pressure, some types of irregular heart rate, thyrotoxicosis, capillary hemangiomas, akathisia, performance anxiety, and essential tremors, as well as to prevent migraine headaches, and to prevent further heart problems in those with angina or previous heart attacks. It can be taken orally, rectally, or by intravenous injection. The formulation that is taken orally comes in short-acting and long-acting versions. Propranolol appears in the blood after 30 minutes and has a maximum effect between 60 and 90 minut
Key facts
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.image
- Propranolol.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 250
- Drug.image2
- Propranolol-from-1977-crystal-structure-3D-balls-side.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 250
- Drug.chirality
- Racemic mixture
- Drug.USAN
- propranolol hydrochloride
- Drug.tradename
- Inderal, others
- Drug.MedlinePlus
- a682607
- Drug.DailyMedID
- Propranolol
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- By mouth, rectal, intravenous
- Drug.class
- Beta blocker
- Drug.ATC_prefix
- C07
- Drug.ATC_suffix
- AA05
via Wikipedia infobox
Chemical data
- Formula
- C16H21NO2
- Molecular weight
- 259.34 g/mol
- IUPAC name
- 1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol
- SMILES
- CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O
- InChIKey
- AQHHHDLHHXJYJD-UHFFFAOYSA-N
- XLogP
- 3
- Polar surface area
- 41.5 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
47,785 papersvia PubMed
Wikidata facts
- Mass
- 259.157229
Show 4 more facts
- Commons category
- Propranolol
- chemical formula
- C₁₆H₂₁NO₂
- canonical SMILES
- CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O
- World Health Organisation international non-proprietary name
- propranolol
via Wikidata · CC0
~21 min read
Article
30 sectionsContents
- Medical uses
- Anxiety and related disorders
- Post-traumatic stress disorder and phobias
- Other uses
- Available forms
- Contraindications
- Side effects
- Pregnancy and lactation
- Overdose
- Interactions
- Pharmacodynamic interactions
- Effects of drugs on propranolol
- Effects of propranolol on other drugs
- Pharmacology
- Pharmacodynamics
- Mechanism of action
- Pharmacokinetics
- Absorption
- Distribution
- Metabolism
- Elimination
- Pharmacogenomics
- Chemistry
- History
- Society and culture
- Performance enhancement
- Brand names
- References
- Further reading
- External links
Propranolol is a medication of the beta blocker class. It is used to treat high blood pressure, some types of irregular heart rate, thyrotoxicosis, capillary hemangiomas, akathisia, performance anxiety, and essential tremors, as well as to prevent migraine headaches, and to prevent further heart problems in those with angina or previous heart attacks. It can be taken orally, rectally, or by intravenous injection. The formulation that is taken orally comes in short-acting and long-acting versions. Propranolol appears in the blood after 30 minutes and has a maximum effect between 60 and 90 minutes when taken orally.
Common side effects include nausea, abdominal pain, and constipation. It may worsen the symptoms of asthma. Propranolol may cause harmful effects for the fetus if taken during pregnancy; however, its use during breastfeeding is generally considered to be safe. It is a non-selective beta blocker which works by blocking β-adrenergic receptors.