Structure via PubChem · Public domain (PubChem)
promazine
Sign in to saveAlso known as N,N-dimethyl-3-(10H-phenothiazin-10-yl)-propan-1-amine, N-dimethylamino-1-methylethyl thiodiphenylamine, N-(3-dimethylaminopropyl)phenothiazine, 10-[3-(dimethylamino)propyl]phenothiazine
Promazine (brand name Sparine among others), is used as a short-term add-on treatment for psychomotor agitation. Its approved uses in people is limited, but is used as a tranquilizer in veterinary medicine. It has weak antipsychotic effects but is generally not used to treat psychosis.
Chemical data
- Formula
- C17H20N2S
- Molecular weight
- 284.4 g/mol
- IUPAC name
- N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine
- SMILES
- CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31
- InChIKey
- ZGUGWUXLJSTTMA-UHFFFAOYSA-N
- XLogP
- 4.5
- Polar surface area
- 31.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
1,380 papers- Perioral photoallergic dermatitis to promazine hydrochloride.Contact dermatitis · 2022
- Promazine Detection in Human Hair: Presentation of an LC-MS-MS Method and Pattern of Drug Discontinuation.Journal of analytical toxicology · 2022
- PROMAZINE hydrochloride.Journal of the American Medical Association · 1957
- Photoallergy to promazine hydrochloride.Contact dermatitis · 2017
- Effect of carbamazepine on the pharmacokinetics of promazine.Polish journal of pharmacology · 1996
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Has part
- carbon
- Mass
- 284.135
- Has use
- medication
Show 7 more facts
- subject has role
- antiemetic
- chemical formula
- C₁₇H₂₀N₂S
- World Health Organisation international non-proprietary name
- promazine
- medical condition treated
- vomiting
- canonical SMILES
- CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31
- physically interacts with
- Dopamine receptor D3
- Commons category
- Promazine
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Uses
- Adverse effects
- Overdose
- Other animals
- Synthesis
- References
Promazine (brand name Sparine among others), is used as a short-term add-on treatment for psychomotor agitation. Its approved uses in people is limited, but is used as a tranquilizer in veterinary medicine. It has weak antipsychotic effects but is generally not used to treat psychosis.
It acts similar to chlorpromazine and causes sedation. It has predominantly anticholinergic side effects, though extrapyramidal side effects are not uncommon. It belongs to the typical antipsychotic and phenothiazine class of drugs.
Excerpted from Wikipedia’s “promazine” article, available under the CC BY-SA 4.0 licence.