buserelin

Also known as buserelin acetate, HOE 766, HOE 766A, ICI 123215, Metrelef®, Suprefact®

Buserelin, sold under the brand name Suprefact among others, is a medication which is used primarily in the treatment of prostate cancer and endometriosis. It is also used for other indications such as the treatment of premenopausal breast cancer, uterine fibroids, and early puberty, in assisted reproduction for female infertility, and as a part of transgender hormone therapy. In addition, buserelin is used in veterinary medicine. The medication is typically used as a nasal spray three times per day, but is also available for use as a solution or implant for injection into fat.

Chemical data

Formula: C60H86N16O13
Molecular weight: 1239.4 g/mol
IUPAC name: (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Protein
Indications: neoplasm, infertility, prostate cancer, prostate adenocarcinoma

via ChEMBL · EBI

Research

2,571 papers

Buserelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical profile.Drugs · 1990
[Buserelin].Deutsche medizinische Wochenschrift (1946) · 1994
Buserelin in the treatment of prostatic cancer.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 1989
Buserelin Promotes the Differentiation and Function of Macrophage-Colony-Stimulating Factor-Producing T Helper Cells.Immunological investigations · 2025
Buserelin Inhibits the Immunosuppressive Activity of Regulatory T Cells through the Protein Kinase A Signaling in a Central Precocious Puberty Model.Immunological investigations · 2022

via PubMed

Wikidata facts

Mass: 1238.656027

Show 4 more facts

chemical formula: C₆₀H₈₆N₁₆O₁₃
canonical SMILES: CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(COC(C)(C)C)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C6CCC(=O)N6
isomeric SMILES: CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6
defined daily dose: 1.5

Sources (3)

via Wikidata · CC0

~11 min read

Article

20 sections

Contents

Medical uses
Dosages
Available forms
Contraindications
Side effects
Overdose
Pharmacology
Pharmacodynamics
Pharmacokinetics
Chemistry
History
Society and culture
Generic names
Brand names
Availability
Research
See also
References
Further reading
External links

Side effects of buserelin are related to sex hormone deprivation and include symptoms of low testosterone levels and low estrogen levels such as hot flashes, sexual dysfunction, vaginal atrophy, and osteoporosis. Buserelin is a gonadotropin-releasing hormone agonist (GnRH agonist) and works by preventing the production of sex hormones by the gonads. It can lower sex hormone levels by about 95% in both sexes. Buserelin is a peptide and an analogue of .