C5AR2
Sign in to saveAlso known as C5L2, GPR77, complement component 5a receptor 2, complement C5a receptor 2, C5a2
Complement component 5a receptor 2 is a protein of the complement system that in humans is encoded by the C5AR2 gene. It is highly expressed in the blood and spleen, predominantly by myeloid cells.
Gene data
C5AR2- Name
- complement C5a receptor 2
- Type
- protein-coding
- Position
- 47,332,148–47,347,329 (+)
- Aliases
- C5L2, GPF77, GPR77
- Ensembl
- ENSG00000134830
- RefSeq RNA
- NM_001271749.2, NM_001271750.2, NM_018485.3
- RefSeq protein
- NP_001258678.1, NP_001258679.1, NP_060955.1
This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
complement C5a receptor 2
- Symbol
- C5AR2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:47,332,148-47,347,329
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 49549
- exact match
- identifiers.org/ncbigene/27202
- genomic end
- 47347329
- genomic start
- 47332175
- cytogenetic location
- 19q13.32
Sources (3)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- Function
- References
Complement component 5a receptor 2 is a protein of the complement system that in humans is encoded by the C5AR2 gene. It is highly expressed in the blood and spleen, predominantly by myeloid cells.
== Function ==