C5AR2

Also known as C5L2, GPR77, complement component 5a receptor 2, complement C5a receptor 2, C5a2

Complement component 5a receptor 2 is a protein of the complement system that in humans is encoded by the C5AR2 gene. It is highly expressed in the blood and spleen, predominantly by myeloid cells.

Gene data

C5AR2

Name: complement C5a receptor 2
Type: protein-coding
Position: 47,332,148–47,347,329 (+)
Aliases: C5L2, GPF77, GPR77
Ensembl: ENSG00000134830
RefSeq RNA: NM_001271749.2, NM_001271750.2, NM_018485.3
RefSeq protein: NP_001258678.1, NP_001258679.1, NP_060955.1

This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].

Gene Ontology

Biological process

complement receptor mediated signaling pathway

Article

2 sections

Contents

Function
References

Complement component 5a receptor 2 is a protein of the complement system that in humans is encoded by the C5AR2 gene. It is highly expressed in the blood and spleen, predominantly by myeloid cells.

== Function ==