Structure via PubChem · Public domain (PubChem)
carmustine
Sign in to saveAlso known as BiCNU®, Carustine®, N,N'-Bis(2-chloroethyl)-N-nitrosourea, Gliadel, Bicnu (TN), Bischloroethyl nitrosourea, BCNU
Carmustine, sold under the brand name BiCNU among others, is a medication used mainly for chemotherapy. It is a nitrogen mustard β-chloro-nitrosourea compound used as an alkylating agent.
Key facts
- Drug.tradename
- BiCNU, Gliadel
- Drug.MedlinePlus
- a682060
- Drug.DailyMedID
- Carmustine
- Drug.class
- Antineoplastic agents
via Wikipedia infobox
Chemical data
- Formula
- C5H9Cl2N3O2
- Molecular weight
- 214.05 g/mol
- IUPAC name
- 1,3-bis(2-chloroethyl)-1-nitrosourea
- SMILES
- C(CCl)NC(=O)N(CCCl)N=O
- InChIKey
- DLGOEMSEDOSKAD-UHFFFAOYSA-N
- XLogP
- 1.5
- Polar surface area
- 61.8 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
4,991 papers- Pharmacokinetics of the carmustine implant.Clinical pharmacokinetics · 2002
- Carmustine wafers: localized delivery of chemotherapeutic agents in CNS malignancies.Expert review of anticancer therapy · 2008
- Carmustine wafer implantation for high-grade gliomas: Evidence-based safety efficacy and practical recommendations from the Neuro-oncology Club of the French Society of Neurosurgery.Neuro-Chirurgie · 2017
- Carmustine induces platelet apoptosis.Platelets · 2015
- The nitrosoureas: carmustine (BCNU) and lomustine (CCNU).Cancer treatment reviews · 1982
via PubMed
Wikidata facts
- Mass
- 213.007
Show 4 more facts
- chemical formula
- C₅H₉Cl₂N₃O₂
- canonical SMILES
- C(CCl)NC(=O)N(CCCl)N=O
- World Health Organisation international non-proprietary name
- carmustine
- Commons category
- Carmustine
Sources (6)
via Wikidata · CC0
~2 min read
Article
8 sectionsContents
- Description
- Mechanism of action
- Uses
- Implants
- Production
- See also
- References
- External links
Carmustine, sold under the brand name BiCNU among others, is a medication used mainly for chemotherapy. It is a nitrogen mustard β-chloro-nitrosourea compound used as an alkylating agent.
==Description== Carmustine is an orange-yellow solid medication used mainly for chemotherapy. It is a nitrogen mustard β-chloro-nitrosourea compound.