CCDC88A
Sign in to saveAlso known as PEHO, APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212, coiled-coil domain containing 88A
Girdin is a protein that in humans is encoded by the CCDC88A gene. Although its cellular function are not fully elucidated, it has been associated with glioma.
In the Vinony graph
Within Vinony's link graph, CCDC88A is referenced by 5 other articles, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 2.
Its subject is documented across 6 Wikipedia language editions.
Gene data
CCDC88A- Name
- coiled-coil and HOOK domain protein 88A
- Type
- protein-coding
- Aliases
- APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212, PEHO, PEHOL
This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
via MyGene.info
Gene · Ensembl
coiled-coil domain containing 88A
- Symbol
- CCDC88A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:55,287,363-55,420,042
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 41180
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/55704
- genomic end
- 55419895
- genomic start
- 55514978
- chromosome
- human chromosome 2
- cytogenetic location
- 2p16.1
- expressed in
- testicle
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- External links
- Further reading
Girdin is a protein that in humans is encoded by the CCDC88A gene. Although its cellular function are not fully elucidated, it has been associated with glioma.
==References==
Excerpted from Wikipedia’s “CCDC88A” article, available under the CC BY-SA 4.0 licence.