CCT6B

Also known as TSA303, CCT-zeta-2, CCTZ-2, Cctz2, TCP-1-zeta-2, chaperonin containing TCP1 subunit 6B

T-complex protein 1 subunit zeta-2 is a protein that in humans is encoded by the CCT6B gene.

In the Vinony graph

Vinony's link graph records 4 inbound references to CCT6B, and connects out to PubMed, human chromosome 17 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 17.

Vinony links it to 6 Wikipedia language editions.

Gene data

CCT6B

Name: chaperonin containing TCP1 subunit 6B
Type: protein-coding
Position: 34,927,842–34,981,078 (−)
Aliases: CCT-zeta-2, CCTZ-2, Cctz2, TCP-1-zeta-2, TSA303
Ensembl: ENSG00000132141
RefSeq RNA: NM_001193529.3, NM_001193530.2, NM_006584.4
RefSeq protein: NP_001180458.1, NP_001180459.1, NP_006575.2

This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].

Gene Ontology

Biological process

protein folding protein folding protein folding

Molecular function

protein binding ATP binding ATP hydrolysis activity ATP hydrolysis activity protein folding chaperone protein folding chaperone ATP-dependent protein folding chaperone

Cellular component

cytoplasm cytoplasm chaperonin-containing T-complex chaperonin-containing T-complex chaperonin-containing T-complex

Pathways

Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Chaperonin-mediated protein folding Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis Protein folding Protein folding

via MyGene.info

Gene · Ensembl

chaperonin containing TCP1 subunit 6B

Symbol: CCT6B
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:34,927,842-34,981,078
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 55978
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/10693
genomic end: 33308097
genomic start: 33254878
chromosome: human chromosome 17
cytogenetic location: 17q12
expressed in: gastric mucosa

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

3 sections

Contents

References
External links
Further reading

T-complex protein 1 subunit zeta-2 is a protein that in humans is encoded by the CCT6B gene.

This gene encodes a molecular chaperone that is a member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Excerpted from Wikipedia’s “CCT6B” article, available under the CC BY-SA 4.0 licence.