CENPO
Sign in to saveAlso known as CENP-O, ICEN-36, MCM21R, centromere protein O
Centromere protein O is a protein that in humans is encoded by the CENPO gene. CENPO is involved in cell proliferation and cell cycle progression and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and neuroblasts and a severe reduction in numbers of neurons produced.
Gene data
CENPO- Name
- centromere protein O
- Type
- protein-coding
- Aliases
- CENP-O, ICEN-36, MCM21R
This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].
via MyGene.info
Gene · Ensembl
centromere protein O
- Symbol
- CENPO
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:24,793,100-24,822,376
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 49760
- genomic start
- 25016005
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/79172
- genomic end
- 25045245
- chromosome
- human chromosome 2
- cytogenetic location
- 2p23.3
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- External links
- Further reading
Centromere protein O is a protein that in humans is encoded by the CENPO gene. CENPO is involved in cell proliferation and cell cycle progression and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and neuroblasts and a severe reduction in numbers of neurons produced.
== References ==
Excerpted from Wikipedia’s “CENPO” article, available under the CC BY-SA 4.0 licence.