cephradine

Key facts

Drug.N

3

Drug.O

4

Drug.S

1

Drug.Watchedfields

changed

Drug.verifiedrevid

443510316

Drug.IUPAC_name

(6R,7R)-7-{[(2R)-2-Amino-2-(1-cyclohexa-1,4-dienyl)acetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Drug.image

Cefradine.svg

Drug.image_class

skin-invert-image

Drug.tradename

Intracef, Velocef

Drug.MedlinePlus

a601206

Drug.legal_status

Rx-only

Drug.routes_of_administration

Oral, IM, IV

Drug.bioavailability

Well absorbed

Drug.protein_bound

<10%

Drug.metabolism

Nil

Drug.elimination_half life

0.9 hours

Drug.excretion

Renal, unchanged

Drug.IUPHAR_ligand

4830

via Wikipedia infobox

Chemical data

Formula

C16H19N3O4S

Molecular weight

349.4 g/mol

IUPAC name

(6R,7R)-7-[[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

SMILES

CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)[C@@H](C3=CCC=CC3)N)SC1)C(=O)O

InChIKey

RDLPVSKMFDYCOR-UEKVPHQBSA-N

XLogP

0.4

Polar surface area

138 Ų

H-bond donors

3

H-bond acceptors

6

Formal charge

0

via PubChem

• [Non-Necrotizing Acute Dermo-Hypodermal Infections: Erysipela and Infectious Cellulitis].Acta medica portuguesa · 2021
• Cephradine-induced interstitial nephritis.Clinical and experimental immunology · 1979
• Cephradine-associated immune neutropenia.The New England journal of medicine · 1985
• Cefadroxil. A review of its antibacterial, pharmacokinetic and therapeutic properties in comparison with cephalexin and cephradine.Drugs · 1986
• Comparative efficacy of cephradine-loaded silver and gold nanoparticles against resistant human pathogens.Artificial cells, nanomedicine, and biotechnology · 2022

via PubMed

Wikidata facts

Mass

349.109627

via Wikidata · CC0