CHD1

Also known as chromodomain helicase DNA binding protein 1, PILBOS, CHD-1

The Chromodomain-Helicase DNA-binding 1 is a protein that, in humans, is encoded by the CHD1 gene. CHD1 is a chromatin remodeling protein that is widely conserved across many eukaryotic organisms, from yeast to humans. CHD1 is named for three of its protein domains: two tandem chromodomains, its ATPase catalytic domain, and its DNA-binding domain (Figure 1).

Gene data

CHD1

Name: chromodomain helicase DNA binding protein 1
Type: protein-coding
Position: 98,853,985–98,929,007 (−)
Aliases: CHD-1, PILBOS
Ensembl: ENSG00000153922
RefSeq RNA: NM_001270.4, NM_001364113.3, NM_001376194.2, NR_157078.3, NR_157079.3
RefSeq protein: NP_001261.2, NP_001351042.1, NP_001363123.1, XP_024310112.1, XP_024310113.1

The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

chromatin remodeling chromatin remodeling nucleosome organization host-mediated activation of viral transcription

Molecular function

DNA binding chromatin binding protein binding ATP binding ATP hydrolysis activity ATP hydrolysis activity histone binding histone H3K4me3 reader activity

Cellular component

nuclear chromosome chromatin nucleus nucleus nucleus nucleoplasm cytoplasm cytoplasm

Pathways

Signal Transduction Chromatin organization ESR-mediated signaling Signaling by Nuclear Receptors Estrogen-dependent gene expression ATP-dependent chromatin remodelers CHD chromatin remodelers CHD1 and CHD2 subfamily

via MyGene.info

Gene · Ensembl

chromodomain helicase DNA binding protein 1

Symbol: CHD1
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:98,853,985-98,929,627
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein CHD1 PDB 2b2t.png

Show 5 more facts

HomoloGene ID: 68174
exact match: identifiers.org/ncbigene/1105
genomic end: 98929007
genomic start: 98190908
cytogenetic location: 5q15-q21.1

Sources (4)

via Wikidata · CC0

~4 min read

Article

7 sections

Contents

Structure
Function
Interactions
Clinical significance
References
Further reading
External links

The CHD1 remodeler binds nucleosomes and induces local changes in nucleosome positioning through ATP hydrolysis coupled to DNA translocation of the DNA across the histone proteins. The catalytic domain of CHD1, which is highly conserved across all nucleosome remodelers, is a two-lobed structure. CHD1 relies on the DNA-binding domain, which binds DNA in a sequence non-specific manner, to help regulate spacing.