chloralose

Chloralose (also known as α-chloralose) is an avicide, and a rodenticide used to kill mice in temperatures below 15 °C. It is also widely used in neuroscience and veterinary medicine as an anesthetic and sedative. Either alone or in combination, such as with urethane, it is used for long-lasting, but light anesthesia. It has been used with oral administration to sedate wild Canada geese for translocation in Nevada.

Chemical data

Formula: C8H11Cl3O6
Molecular weight: 309.5 g/mol
IUPAC name: (1R)-1-[(2R,3aR,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol
SMILES: C([C@H]([C@@H]1[C@@H]([C@@H]2[C@H](O1)O[C@@H](O2)C(Cl)(Cl)Cl)O)O)O
InChIKey: OJYGBLRPYBAHRT-IPQSZEQASA-N
XLogP: 1
Polar surface area: 88.4 Å²
H-bond donors: 3
H-bond acceptors: 6
Formal charge: 0

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Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule

via ChEMBL · EBI

Research

5,580 papers

The pharmacology of chloralose. A review.Psychopharmacologia · 1964
[Alpha-chloralose].Tijdschrift voor diergeneeskunde · 1992
Alpha-chloralose as a canine anesthetic.Laboratory animal science · 1987
Pharmacology and toxicology of alpha chloralose: a review.The Veterinary record · 1972
A review of laboratory animal anesthesia with chloral hydrate and chloralose.Laboratory animal science · 1993

via PubMed

Wikidata facts

Mass: 307.962
Has use: rodenticide

Show 5 more facts

melting point: 183
chemical formula: C₈H₁₁Cl₃O₆
Commons category: Chloralose
canonical SMILES: C(C(C1C(C2C(O1)OC(O2)C(Cl)(Cl)Cl)O)O)O
isomeric SMILES: C([C@H]([C@@H]1[C@@H]([C@@H]2[C@H](O1)O[C@@H](O2)C(Cl)(Cl)Cl)O)O)O

Sources (3)

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Encyclopedic overview

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Contents

References

Chemically, it is a chlorinated acetal derivative of glucose.

Excerpted from Wikipedia’s “chloralose” article, available under the CC BY-SA 4.0 licence.

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