Structure via PubChem · Public domain (PubChem)
cicletanine
Sign in to saveCicletanine is a furopyridine compound (i.e., has a pyridine ring fused to a furan ring) that is approved in France for the treatment of hypertension. The drug is most commonly known as a diuretic drug, but has a broader range of cardiovascular and metabolic activity characterized extensively in the literature (see "Mechanism" below).
In the Vinony graph
Within Vinony's link graph, cicletanine is referenced by 75 other articles, and connects out to medication, collecting duct system and International Standard Book Number.
Vinony files it under 4-Chlorophenyl compounds, Chemical pages without DrugBank identifier and Diuretics.
Its subject is documented across 5 Wikipedia language editions.
Chemical data
- Formula
- C14H12ClNO2
- Molecular weight
- 261.7 g/mol
- IUPAC name
- 3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol
- SMILES
- CC1=NC=C2C(OCC2=C1O)C3=CC=C(C=C3)Cl
- InChIKey
- CVKNDPRBJVBDSS-UHFFFAOYSA-N
- XLogP
- 2.4
- Polar surface area
- 42.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- pulmonary arterial hypertension, cardiovascular disease
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 261.056
Show 3 more facts
- chemical formula
- C₁₄H₁₂ClNO₂
- canonical SMILES
- CC1=NC=C2C(OCC2=C1O)C3=CC=C(C=C3)Cl
- subject has role
- diuretic
Sources (2)
via Wikidata · CC0
~3 min read
Encyclopedic overview
3 sectionsContents
- Mechanism
- References
- External links
Cicletanine is a furopyridine compound (i.e., has a pyridine ring fused to a furan ring) that is approved in France for the treatment of hypertension. The drug is most commonly known as a diuretic drug, but has a broader range of cardiovascular and metabolic activity characterized extensively in the literature (see "Mechanism" below).
Cicletanine was originated and in 1986 launched in France by Paris-based Ipsen, who in 2005 licensed marketing rights in France to Milan-based Recordati for several years (at least until 2010). Ipsen and Recordati both marketed cicletanine under the trade name Tenstaten. The drug is no longer manufactured nor sold by IPSEN; it is currently marketed in France by three generics manufacturers: Viatris, Biogaran, and Teva Pharmaceuticals.
Excerpted from Wikipedia’s “cicletanine” article, available under the CC BY-SA 4.0 licence.