Coagulation factor XII

Protein · UniProt

Coagulation factor XII

Gene

F12

Organism

Homo sapiens (Human)

Length

615 aa

Molecular mass

67,792 Da

Evidence

1: Evidence at protein level

Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (PubMed:2019570, PubMed:21304106, PubMed:8427954)

• Coagulation factor XII in thrombosis and inflammation.Blood · 2018
• Factor XII in coagulation, inflammation and beyond.Cellular signalling · 2018
• Coagulation factor XII haploinsufficiency is protective against venous thromboembolism in a population-scale multidimensional analysis.Nature communications · 2025
• The Coagulation Factors Fibrinogen, Thrombin, and Factor XII in Inflammatory Disorders-A Systematic Review.Frontiers in immunology · 2018
• Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease.Nature communications · 2024

via PubMed

• NAUNKNOWN
  The Proteins of the Contact Activation SystemHospices Civils de Lyon · NCT02785718
• UNKNOWN
  Thrombus Formation Under Different Flow-conditionsMaastricht University Medical Center · NCT01114074
• COMPLETED
  The Contact Activation System and Ulcerative ColitisEsbjerg Hospital - University Hospital of Southern Denmark · NCT04621006
• PHASE1COMPLETED
  Phase 1 Safety and Tolerability Study of REGN9533 in Healthy AdultsRegeneron Pharmaceuticals · NCT06665828
• PHASE1ACTIVE_NOT_RECRUITING
  Phase 1 Safety and Tolerability Study of ALN-F1202 in Healthy AdultsRegeneron Pharmaceuticals · NCT06669234
• COMPLETED
  Risk Markers in the Acute Coronary SyndromesHelse Stavanger HF · NCT00521976

via ClinicalTrials.gov