conivaptan
Sign in to saveAlso known as Vaprisol®, YM-087, YM087, 4'-((4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1H)-yl)carbonyl)-2-biphenylcarboxanilide, 4'-((4,5-dihydro-2-Methylimidazo(4,5-D)(1)benzazepin-6(1H)-yl)carbonyl)-2-biphenylcarboxanilide
Conivaptan, sold under the brand name Vaprisol, is a non-peptide inhibitor of the receptor for anti-diuretic hormone, also called vasopressin. It was approved in 2004 for hyponatremia (low blood sodium levels). Additionally, conivaptan is used for the treatment of syndrome of inappropriate antidiuretic hormone secretion.
Research
281 papers- Conivaptan: YM 087.Drugs in R&D · 2004
- Conivaptan: new treatment for hyponatremia.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2007
- Conivaptan (Yamanouchi).Current opinion in investigational drugs (London, England : 2000) · 2002
- Conivaptan for treatment of hyponatremia in neurologic and neurosurgical adults.The Annals of pharmacotherapy · 2013
- Conivaptan: a dual vasopressin receptor v1a/v2 antagonist [corrected].Cardiovascular drug reviews · 2007
via PubMed
Wikidata facts
- Mass
- 498.205576
Show 4 more facts
- chemical formula
- C₃₂H₂₆N₄O₂
- canonical SMILES
- CC1=NC2=C(N1)CCN(C3=CC=CC=C32)C(=O)C4=CC=C(C=C4)NC(=O)C5=CC=CC=C5C6=CC=CC=C6
- World Health Organisation international non-proprietary name
- conivaptan
- Commons category
- Conivaptan
Sources (2)
via Wikidata · CC0
~5 min read
Article
7 sectionsContents
- Medical uses
- Pharmacology
- Adverse effects
- Chemistry
- History
- References
- External links
Conivaptan, sold under the brand name Vaprisol, is a non-peptide inhibitor of the receptor for anti-diuretic hormone, also called vasopressin. It was approved in 2004 for hyponatremia (low blood sodium levels). Additionally, conivaptan is used for the treatment of syndrome of inappropriate antidiuretic hormone secretion.
Conivaptan inhibits two of the three subtypes of the vasopressin receptor (V1A and V2). Effectively, it causes iatrogenic nephrogenic diabetes insipidus.
Available in 11 languages
via Wikidata sitelinks · CC0