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daledalin

Structure via PubChem · Public domain (PubChem)

EntityQ5210732· pop 6· linked from 897 articles

Also known as UK-3557-15

Daledalin (UK-3557-15) is an antidepressant which was synthesized and trialed for depression in the early 1970s, but was never marketed. It is a selective norepinephrine reuptake inhibitor, with no significant effects on the reuptake of serotonin and dopamine, and no antihistamine or anticholinergic properties.

In the Vinony graph

Within Vinony's link graph, daledalin is referenced by 897 other articles, and connects out to histamine antagonist, tetracyclic antidepressant and adrenergic uptake inhibitors.

It is catalogued under topics including Abandoned drugs, Antidepressants and Chemical pages without DrugBank identifier.

Its subject is documented across 5 Wikipedia language editions.

Chemical data

Formula
C19H24N2
Molecular weight
280.4 g/mol
IUPAC name
N-methyl-3-(3-methyl-1-phenyl-2H-indol-3-yl)propan-1-amine
SMILES
CC1(CN(C2=CC=CC=C21)C3=CC=CC=C3)CCCNC
InChIKey
YFAIJBZEDDOCAN-UHFFFAOYSA-N
XLogP
4.3
Polar surface area
15.3 Ų
H-bond donors
1
H-bond acceptors
2
Formal charge
0

via PubChem

Drug data · ChEMBL

Max clinical phase
Phase 2
Molecule type
Small molecule

via ChEMBL · EBI

Wikidata facts

Mass
280.193949
Show 3 more facts
chemical formula
C₁₉H₂₄N₂
canonical SMILES
CC1(CN(C2=CC=CC=C21)C3=CC=CC=C3)CCCNC
Commons category
Daledalin
Sources (2)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections
Contents
  • Synthesis
  • References

Daledalin (UK-3557-15) is an antidepressant which was synthesized and trialed for depression in the early 1970s, but was never marketed. It is a selective norepinephrine reuptake inhibitor, with no significant effects on the reuptake of serotonin and dopamine, and no antihistamine or anticholinergic properties.

==Synthesis== Daledalin can be prepared by the reduction of amedalin with diborane. thumb|left|500px|class=skin-invert-image|Daledalin synthesis

Excerpted from Wikipedia’s “daledalin” article, available under the CC BY-SA 4.0 licence.

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