DENND1A
Sign in to saveAlso known as FAM31A, KIAA1608, DENN domain containing 1A
DENN domain-containing protein 1A is a protein that in humans is encoded by the DENND1A gene.
Gene data
DENND1A- Name
- DENN domain containing 1A
- Type
- protein-coding
- Position
- 123,379,648–123,930,152 (−)
- Aliases
- FAM31A, KIAA1608
- Ensembl
- ENSG00000119522
- RefSeq RNA
- NM_001352964.2, NM_001352965.2, NM_001352966.2, NM_001352967.2, NM_001352968.2
- RefSeq protein
- NP_001339893.1, NP_001339894.1, NP_001339895.1, NP_001339896.1, NP_001339897.1
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
DENN domain containing 1A
- Symbol
- DENND1A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:123,379,648-123,930,154
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 17141
- exact match
- identifiers.org/ncbigene/57706
- genomic start
- 126141933
- genomic end
- 126692431
- cytogenetic location
- 9q33.3
via Wikidata · CC0
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Article
2 sectionsContents
- References
- Further reading
DENN domain-containing protein 1A is a protein that in humans is encoded by the DENND1A gene.
==References==