DCTN1

Also known as DAP-150, DP-150, P135, dynactin subunit 1

Dynactin subunit 1 is a protein that in humans is encoded by the DCTN1 gene.

In the Vinony graph

Within Vinony's link graph, DCTN1 is referenced by 281 other articles, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.

Vinony files it under Genes on human chromosome 2 and Long stubs with short prose.

Its subject is documented across 6 Wikipedia language editions.

Gene data

DCTN1

Name: dynactin subunit 1
Type: protein-coding
Position: 74,361,154–74,392,087 (−)
Aliases: DAP-150, DP-150, HMND14, P135
Ensembl: ENSG00000204843
RefSeq RNA: NM_001135040.3, NM_001135041.3, NM_001190836.2, NM_001190837.2, NM_001378991.1
RefSeq protein: NP_001128512.1, NP_001128513.1, NP_001177765.1, NP_001177766.1, NP_001365920.1

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008].