DYNLT1

Also known as CW-1, TCTEL1, tctex-1, dynein light chain Tctex-type 1, TCTEX1

Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene.

Gene data

DYNLT1

Name: dynein light chain Tctex-type 1
Type: protein-coding
Aliases: CW-1, TCTEL1, TCTEX1, tctex-1

This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014].

via MyGene.info

Gene · Ensembl

dynein light chain Tctex-type 1

Symbol: DYNLT1
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:158,612,721-158,644,771
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 4754
exact match: identifiers.org/ncbigene/6993
genomic start: 159057506
genomic end: 158644743
cytogenetic location: 6q25.3

Sources (4)

via Wikidata · CC0

~1 min read

Article

2 sections

Contents

References
Further reading

Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene.

Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005).[supplied by OMIM]